PURPOSES To investigate the relationship between apparent diffusion coefficient (ADC) value and p53 and ki-67 expression in esophageal squamous cell carcinoma (ESCC) patients. MATERIALS AND METHODS Clinical, pathologic and MRI findings of 55 ESCC patients were retrospectively analyzed. Immunohistochemical assay was used to determine the expression level of p53 and ki-67 in esophageal carcinoma tissues. The correlations between the ADC value (including ADCmax, ADCmean and ADCmin) and p53 and ki-67 expression level were explored. RESULTS Significant differences of the ADCmean values were found between positive and negative expression of p53 and between high and low expression of ki-67 in 55 patients of ESCC (P = 0.008, P = 0.036). Receiver operation characteristic (ROC) curve analysis showed that the cutoff value of ADCmean value with positive expression of p53 was 1.475 × 10-3 mm2/s, the area under the curve (AUC) was 0.775, and the sensitivity and specificity were 80.0%, 70.0%, respectively. While the cutoff value for the ADCmean value with high expression of ki-67 was 1.590 × 10-3 mm2/s, the AUC was 0.713, and the sensitivity and specificity were 66.7%, 76.5%, respectively. The ADCmean values were significantly negatively correlated with the expression level of p53 and ki-67 (r = -0.403, P = 0.008; r = -0.329, P = 0.036). CONCLUSION The ADCmean values of ESCC were related with the expression level of p53 and ki-67 in tumor tissue, which may be served as a non-invasive biological indicator to predict the proliferation of ESCC cells and judge the prognosis of patients.

中文翻译：

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食管鳞状细胞癌表观扩散系数值与P53和Ki-67表达的相关性分析

目的探讨食管鳞状细胞癌（ESCC）患者表观扩散系数（ADC）值与p53和ki-67表达之间的关系。材料与方法回顾性分析55例ESCC患者的临床，病理和MRI表现。免疫组织化学法检测p53和ki-67在食管癌组织中的表达水平。探索了ADC值（包括ADCmax，ADCmean和ADCmin）与p53和ki-67表达水平之间的相关性。结果55例食管鳞癌患者中p53阳性表达和阴性表达以及ki-67高表达和低表达之间的ADCmean值均存在显着差异（P = 0.008，P = 0.036）。接收者操作特征（ROC）曲线分析显示，p53阳性表达的ADCmean值的截断值为1.475×10-3 mm2 / s，曲线下面积（AUC）为0.775，灵敏度和特异性为80.0％ ，分别为70.0％。高表达ki-67的ADCmean值的临界值为1.590×10-3 mm2 / s，AUC为0.713，灵敏度和特异性分别为66.7％，76.5％。ADC平均值与p53和ki-67的表达水平显着负相关（r = -0.403，P = 0.008； r = -0.329，P = 0.036）。结论ESCCC的ADCmean值与肿瘤组织中p53和ki-67的表达水平有关，可作为预测ESCC细胞增殖和判断患者预后的非侵入性生物学指标。