In mammals, 24-h rhythms of behaviour and physiology are regulated by the circadian clock. The circadian clock is controlled by a central clock in the brain's suprachiasmatic nucleus (SCN) that synchronizes peripheral clocks in peripheral tissues. Clock genes in the SCN are primarily entrained by light. Increasing evidence has shown that peripheral clocks are also regulated by light and hormones independent of the SCN. How the peripheral clocks deal with internal signals is dependent on the relevance of a specific cue to a specific tissue. In different tissues, most genes that are under circadian control are not overlapping, revealing the tissue-specific control of peripheral clocks. We will discuss how different signals control the peripheral clocks in different peripheral tissues, such as the liver, gastrointestinal tract, and pancreas, and discuss the organ-to-organ communication between the peripheral clocks at the molecular level.

中文翻译：

---

信号携带外围生物钟。

在哺乳动物中，昼夜节律调节行为和生理的24小时节律。昼夜节律时钟由大脑上视神经上核（SCN）中的中央时钟控制，该时钟使周围组织中的周围时钟同步。SCN中的时钟基因主要被光夹带。越来越多的证据表明，外围时钟也受光和激素的调节，而与SCN无关。外围时钟如何处理内部信号取决于特定提示与特定组织的相关性。在不同的组织中，大多数处于昼夜节律控制下的基因并不重叠，从而揭示了外围时钟的组织特异性控制。我们将讨论不同信号如何控制不同外围组织（例如肝脏，胃肠道和胰腺）中的外围时钟，