Only 41% of clinical trials reported their results to the US clinical trials registry within a year of completion as required by law, a study found. Researchers from Oxford University, UK, who identified 2497 clinical trials that had breached the rules, called for better enforcement from the US Food and Drug Administration. The FDA Amendments Act 2007 requires trial sponsors to report results directly to ClinicalTrials.gov within one year of completion, whether results are positive or negative.
Medical leaders in the UK warned that doctors and patients were being placed at risk after an NHS hospital encouraged doctors to discharge patients early because of a lack of beds. In an internal email to senior clinicians the Royal Cornwall Hospitals Trust had said that it was considering discharging patients “earlier than some clinicians would like” because of “significant pressure” on services. Chaand Nagpaul, BMA council chair, said that the BMA was writing to the trust and the General Medical Council to express “serious concerns.” (Full story doi:10.1136/bmj.m164)
Cancer-causing HPV 16 and 18 infections are now extremely uncommon in young sexually active women in England after the introduction of human papillomavirus (HPV) vaccination in 2008, said Public Health England. The infections were found in under 2% of women aged 16-18 in 2014-18, down from 15% in 2008. HPV …

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一项研究发现，只有41％的临床试验根据法律要求在完成的一年内向美国临床试验注册中心报告了其结果。来自英国牛津大学的研究人员确定了2497个违反规定的临床试验，呼吁美国食品和药物管理局加强执法。《 2007年FDA修正法案》要求试验赞助者必须在完成后一年内直接向ClinicalTrials.gov报告结果，无论结果是阳性还是阴性。
英国的医疗领导者警告说，在NHS医院鼓励医生由于床位不足而尽早出院后，医生和病人正处于危险之中。皇家康沃尔医院信托基金会在致高级临床医生的内部电子邮件中表示，由于对服务的“巨大压力”，正在考虑“比某些临床医生希望的更早”出院患者。BMA委员会主席Chaand Nagpaul表示，BMA正在写信给信托基金和美国医学总会，以表达“严重关切”。（全文doi：10.1136 / bmj.m164）
英格兰公共卫生组织表示，自2008年引入人乳头瘤病毒（HPV）疫苗接种以来，在英格兰的年轻性活跃女性中，致癌的HPV 16和18感染现在已极为罕见。2014-18年，在16-18岁的女性中，感染率不到2％，低于2008年的15％。HPV…