Palladium‐Catalyzed Regioselective C−H Arylation of Quinoline‐N‐Oxides at C‐8 Position using Diaryliodonium Salts,Asian Journal of Organic Chemistry

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Palladium‐Catalyzed Regioselective C−H Arylation of Quinoline‐N‐Oxides at C‐8 Position using Diaryliodonium Salts
Asian Journal of Organic Chemistry ( IF 2.8 ) Pub Date : 2020-02-13 , DOI: 10.1002/ajoc.202000028
Shivani Sharma ₁ , Sehdev Kumar ₁ , Anuj Sharma ₁

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A simple and efficient Pd(II)‐catalyzed site‐selective direct arylation strategy was demonstrated for the synthesis of 8‐arylquinoline‐N‐oxide derivatives using quinoline‐N‐oxides and (aryl)(mesityl)iodonium triflates. A series of control experiments were carried out to elucidate the reaction mechanism. The synthetic potential was extended with the C‐2 post‐modification of the final derivative.

中文翻译：

使用二芳基碘鎓盐在C-8位置进行钯催化的喹啉-N-氧化物的区域选择性CH芳基化

一个简单的和有效的钯（II） -催化位点选择性直接芳基化策略被证明为8 arylquinoline-的合成Ñ使用喹啉衍生物氧化物Ñ -oxides和（芳基）（均三甲苯基）碘鎓三氟甲磺酸酯。进行了一系列对照实验以阐明反应机理。最终衍生物的C-2后修饰扩大了合成潜力。

更新日期：2020-04-21

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