Transplanting cells from old but not young donors causes physical dysfunction in older recipients.,Aging Cell

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Transplanting cells from old but not young donors causes physical dysfunction in older recipients.
Aging Cell ( IF 8.0 ) Pub Date : 2020-01-23 , DOI: 10.1111/acel.13106
Binsheng Wang _{1,

2} , Zukai Liu _{1,

2,

3} , Vicky P Chen ₄ , Lichao Wang _{1,

2} , Christina L Inman ₅ , Yueying Zhou _{6,

7} , Chun Guo _{5,

7} , Tamar Tchkonia ₅ , David W Rowe ₇ , George A Kuchel ₁ , Paul Robson _{2,

8} , James L Kirkland ₅ , Ming Xu _{1,

2,

5}

Affiliation

Adipose‐derived mesenchymal stem cell (ADSC)‐based regenerative therapies have shown potential for use in many chronic diseases. Aging diminishes stem cell regenerative potential, yet it is unknown whether stem cells from aged donors cause adverse effects in recipients. ADSCs can be obtained using minimally invasive approaches and possess low immunogenicity. Nevertheless, we found that transplanting ADSCs from old donors, but not those from young donors, induces physical dysfunction in older recipient mice. Using single‐cell transcriptomic analysis, we identified a naturally occurring senescent cell‐like population in ADSCs primarily from old donors that resembles in vitro‐generated senescent cells with regard to a number of key pathways. Our study reveals a previously unrecognized health concern due to ADSCs from old donors and lays the foundation for a new avenue of research to devise interventions to reduce harmful effects of ADSCs from old donors.

中文翻译：

从年老而非年轻的供体移植细胞会导致年长受体的身体功能障碍。

基于脂肪来源的间充质干细胞 (ADSC) 的再生疗法已显示出用于许多慢性疾病的潜力。衰老会降低干细胞的再生潜力，但尚不清楚来自老年供体的干细胞是否会对受体产生不利影响。ADSCs 可以使用微创方法获得并且具有低免疫原性。尽管如此，我们发现从老年供体移植 ADSC，而不是从年轻供体移植 ADSC，会导致老年受体小鼠出现身体功能障碍。使用单细胞转录组学分析，我们在 ADSCs 中鉴定出一种天然存在的衰老细胞样群体，主要来自老供体，在许多关键途径方面类似于体外产生的衰老细胞。

更新日期：2020-01-23

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