We recently read the interesting paper published in GUT elucidating the role of upstream stimulatory factor 1 (USF1) in Helicobacter pylori (Hp )-induced p53 degradation.1 The work greatly broadens our knowledge of the interplay between Hp and p53 during gastric carcinogenesis. Here we propose some additional exploration, if incorporated in study design, can further deepen our understanding. The significance of USF1 in gastric carcinogenesis should be acknowledged as the study showed that loss of USF1, on its own, exacerbated the severity of …

中文翻译：

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幽门螺杆菌与p53之间复杂的对话

我们最近阅读了发表在 GUT 上的有趣论文，该论文阐明了上游刺激因子 1 (USF1) 在幽门螺杆菌 (Hp) 诱导的 p53 降解中的作用。1 这项工作极大地拓宽了我们对胃癌发生过程中 Hp 和 p53 之间相互作用的认识。在这里我们提出一些额外的探索，如果纳入研究设计，可以进一步加深我们的理解。USF1 在胃癌发生中的重要性应该得到承认，因为该研究表明 USF1 的缺失本身就加剧了……的严重程度。