Self‐healing injectable hydrogel biomaterials uniquely enable precise therapeutic deposition and deployment at specific bodily locations through versatile and minimally invasive processes that can preserve cargo integrity and cell viability. Despite the distinct advantages that injectable hydrogels offer in tissue engineering and therapeutic delivery, exceptionally few have been created using components naturally present in the cellular niche. In this work, we introduce a shear‐thinning hydrogel based on guest‐host complexation of gelatin. As a biocompatible, biodegradable, and nonimmunogenic biopolymer derived from the most abundant extracellular matrix protein (collagen), gelatin offers great utility as the structural component of biomaterials. Taking advantage of reversible guest‐host interactions between β‐cyclodextrin (CD) and adamantane (AD) on modified gelatins, we report the first strategy to afford a self‐healing material based solely on a functionalized extracellular matrix protein. By varying the initial material formulation, hydrogels were synthesized with variable moduli and shear‐thinability across a broad range. Gels were demonstrated to exhibit shear‐thinning and self‐healing properties, supporting protection of clinically relevant stem‐cell‐derived cardiomyocytes during injection. These materials are expected to expand clinical opportunities in cell delivery for in vivo tissue regeneration.

中文翻译：

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用于局部治疗细胞输送的自愈式可注射明胶水凝胶。


自修复可注射水凝胶生物材料独特地能够通过多功能和微创过程在特定的身体部位进行精确的治疗沉积和部署，从而保持货物的完整性和细胞活力。尽管可注射水凝胶在组织工程和治疗递送方面具有明显的优势，但使用细胞生态位中天然存在的成分来制造的水凝胶却很少。在这项工作中，我们介绍了一种基于明胶客体络合的剪切稀化水凝胶。作为一种源自最丰富的细胞外基质蛋白（胶原蛋白）的生物相容性、可生物降解和非免疫原性生物聚合物，明胶作为生物材料的结构成分具有巨大的用途。利用改性明胶上 β-环糊精 (CD) 和金刚烷 (AD) 之间的可逆客主相互作用，我们报告了第一个提供仅基于功能化细胞外基质蛋白的自修复材料的策略。通过改变初始材料配方，合成了在广泛范围内具有可变模量和剪切稀性的水凝胶。凝胶被证明具有剪切稀化和自愈特性，支持在注射过程中保护临床相关的干细胞衍生的心肌细胞。这些材料有望扩大细胞输送用于体内组织再生的临床机会。