Replacement of the Acrid tert‐Butylthiol and an Improved Isolation Protocol for Cysteine Lipidation on a Peptide or Amino Acid (CLipPA),European Journal of Organic Chemistry

当前位置： X-MOL 学术 › Eur. J. Org. Chem. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Replacement of the Acrid tert‐Butylthiol and an Improved Isolation Protocol for Cysteine Lipidation on a Peptide or Amino Acid (CLipPA)
European Journal of Organic Chemistry ( IF 2.5 ) Pub Date : 2020-02-17 , DOI: 10.1002/ejoc.201901696
Sung-Hyun Yang _{1,

2} , Yann O. J. Hermant _{1,

2,

3} , Paul W. R. Harris _{1,

2,

3} , Margaret A. Brimble _{1,

2,

3}

Affiliation

The late stage S‐lipidation of unprotected peptides, a process we have coined CLipPA (Cysteine Lipidation of a Peptide or Amino acid) was optimized. The offensively smelly tBuSH was replaced with the more benign, t‐NonylSH and the lipopeptides could readily be recovered with an improved isolation procedure.