BACKGROUND Progressive spinal deformity has become a well-recognized complication of intracanal tumors resection. However, the factors affecting post-operative spinal stability remain to be further research. Here, we described the current largest series of risk factors analysis for progressive spinal deformity following resection of intracanal tumors. METHODS We retrospectively analyzed the medical records of the patients with resection of intracanal tumors between January 2009 and December 2018. All patients who underwent resection of intracanal tumors performed regular postoperative follow-up were identified and included in the study. Clinical, radiological, surgical, histopathological, and follow-up data were collected. The incidence of postoperative progressive kyphosis or scoliosis was calculated. The statistical relationship between postoperative progressive spinal deformity and radiographic, clinical, and surgical variables was assessed by using univariate tests and multivariate logistic regression analysis. RESULTS Two hundred seventy-two patients (mean age 42.56 ± 16.18 years) with median preoperative modified McCormick score of 3 met the inclusion criteria. Among them, 7(2.6%)patients were found to have spinal deformity preoperatively, and the extent of spinal deformity in these 7 patients deteriorated after surgery. 36 (13.2%) were new cases of postoperative progressive deformity. The mean duration of follow-up was 21.8 months (median 14 months, range 6-114 months). In subsequent multivariate logistic regression analysis, age ≤ 18 years (p = 0.027), vertebral levels of tumor involvement (p = 0.019) and preoperative spinal deformity(p = 0.008) was the independent risk factors (p < 0.05), increasing the odds of postoperative progressive spinal deformity by 3.94-, 0.69- and 27.11-fold, respectively. CONCLUSIONS The incidence of postoperative progressive spinal deformity was 15.8%, mostly in these patients who had younger age (≤18 years), tumors involved in multiple segments and preoperative spinal deformity. The risk factors of postoperative progressive spinal deformity warrants serious reconsideration that when performing resection of spinal cord tumors in these patients with such risk factors, the surgeons should consider conducting follow-ups more closely, and when patients suffering from severe symptoms or gradually increased spinal deformity, surgical spinal fusion may be a more suitable choice to reduce the risk of reoperation and improve the prognosis of patients.

中文翻译：

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根管内肿瘤切除术后进行性脊柱畸形的危险因素分析－回顾性研究272例。

背景技术进行性脊柱畸形已成为公认的管内肿瘤切除并发症。但是，影响术后脊柱稳定性的因素仍有待进一步研究。在这里，我们描述了目前最大的一系列危险因素分析，用于根管内肿瘤切除术后进行性脊柱畸形。方法我们回顾性分析了2009年1月至2018年12月间切除了根管内肿瘤的患者的病历。确定了所有接受根管内肿瘤切除的患者，并对其进行了定期的术后随访，并将其纳入研究。收集临床，放射，外科，组织病理学和随访数据。计算术后进行性后凸畸形或脊柱侧弯的发生率。术后进行性脊柱畸形与X线，临床和手术变量之间的统计关系通过单变量检验和多因素Logistic回归分析进行评估。结果272例术前改良McCormick评分中位数为3的患者（平均年龄42.56±16.18岁）符合纳入标准。其中，术前发现7例（2.6％）脊柱畸形，这7例患者的脊柱畸形程度在手术后恶化。术后进行性畸形的新病例为36（13.2％）。平均随访时间为21.8个月（中位14个月，范围6-114个月）。在随后的多因素Logistic回归分析中，年龄≤18岁（p = 0.027），椎骨受累的椎体水平（p = 0。019）和术前脊柱畸形（p = 0.008）是独立的危险因素（p <0.05），使术后进行性脊柱畸形的几率分别增加了3.94-，0.69-和27.11-倍。结论术后进行性脊柱畸形的发生率为15.8％，其中大多数患者年龄较小（≤18岁），肿瘤累及多个节段和术前脊柱畸形。术后进行性脊柱畸形的危险因素值得认真考虑，当对具有此类危险因素的这些患者进行脊髓肿瘤切除时，外科医生应考虑更密切地随访，并且当患者出现严重症状或脊柱畸形逐渐增加时，