AIM Oxidative stress is known to increase the risk of insulin resistance (IR). The aim of this study was to investigate the association between stress hormones and IR in women with gestational diabetes mellitus (GDM), in an attempt to gain insights into the pathogenesis of GDM. METHODS Recruited in this study were 70 GDM women and 70 healthy pregnant women as control. Malondialdehyde (MDA), superoxide dismutase (SOD), glutathione (GSH), plasma epinephrine (E), noradrenaline (NE), glucagon, and cortisol levels were detected. IR was assessed by homeostasis model assessment of IR (HOMA-IR) in both groups. Correlations among stress hormones, oxidative stress, and IR were analyzed by Pearson's correlation after log transformation. RESULTS Compared with the Control group, MDA was increased and anti-oxidative enzymes SOD and GSH were decreased significantly in the GDM group. Glucagon, E, and NE in the GDM group were increased by 22.42%, 36.82%, and 35.09%, respectively, as compared with those in the Control group. MDA showed a significant positive correlation, and SOD showed a negative correlation with HOMA-IR in the GDM group. In addition, HOMA-IR was positively related to glucagon, E, NE, and cortisol. CONCLUSIONS Elevation of stress hormones and stress adaptation disturbance may be associated with the pathogenesis of GDM in pregnant women.

中文翻译：

---

压力适应与妊娠糖尿病妇女的胰岛素抵抗有关。

目的已知氧化应激会增加胰岛素抵抗（IR）的风险。这项研究的目的是调查妊娠糖尿病（GDM）妇女的应激激素与IR之间的关系，以期深入了解GDM的发病机理。方法本研究招募了70名GDM妇女和70名健康孕妇作为对照。检测到丙二醛（MDA），超氧化物歧化酶（SOD），谷胱甘肽（GSH），血浆肾上腺素（E），去甲肾上腺素（NE），胰高血糖素和皮质醇水平。两组均通过IR稳态模型评估（HOMA-IR）评估IR。对数转换后，通过皮尔森相关性分析了应激激素，氧化应激和IR之间的相关性。结果与对照组相比，GDM组MDA升高，抗氧化酶SOD和GSH明显降低。与对照组相比，GDM组的胰高血糖素，E和NE分别增加了22.42％，36.82％和35.09％。GDM组中MDA呈显着正相关，SOD与HOMA-IR呈负相关。此外，HOMA-IR与胰高血糖素，E，NE和皮质醇呈正相关。结论孕妇激素水平升高和应激适应障碍可能与GDM的发病机制有关。GDM组中SOD与HOMA-IR呈负相关。此外，HOMA-IR与胰高血糖素，E，NE和皮质醇呈正相关。结论孕妇激素水平升高和应激适应障碍可能与GDM的发病机制有关。GDM组中SOD与HOMA-IR呈负相关。此外，HOMA-IR与胰高血糖素，E，NE和皮质醇呈正相关。结论孕妇激素水平升高和应激适应障碍可能与GDM的发病机制有关。