当前位置：
X-MOL 学术
›
ACS Biomater. Sci. Eng.
›
论文详情
Our official English website, www.x-mol.net, welcomes your
feedback! (Note: you will need to create a separate account there.)
Biodegradable Mg Implants Suppress the Growth of Ovarian Tumor
ACS Biomaterials Science & Engineering ( IF 5.4 ) Pub Date : 2020-02-03 , DOI: 10.1021/acsbiomaterials.9b01703 Shuang Qiao 1 , Yongjie Wang 2 , Rui Zan 1 , Hongliu Wu 1 , Yu Sun 1 , Hongzhou Peng 1 , Rui Zhang 3 , Yang Song 4 , Jiahua Ni 5 , Shaoxiang Zhang 6 , Xiaonong Zhang 1
ACS Biomaterials Science & Engineering ( IF 5.4 ) Pub Date : 2020-02-03 , DOI: 10.1021/acsbiomaterials.9b01703 Shuang Qiao 1 , Yongjie Wang 2 , Rui Zan 1 , Hongliu Wu 1 , Yu Sun 1 , Hongzhou Peng 1 , Rui Zhang 3 , Yang Song 4 , Jiahua Ni 5 , Shaoxiang Zhang 6 , Xiaonong Zhang 1
Affiliation
|
The common treatment of epithelial ovarian cancer is aggressive surgery followed by platinum-based cytotoxic chemotherapy. However, residual tumor cells are resistant to chemotherapeutic drugs during postoperative recurrence. The treatment of ovarian cancer requires breakthroughs and advances. In recent years, magnesium alloy has been widely developed as a new biodegradable material because of its great potential in the field of medical devices. From the degradation products of magnesium, biodegradable magnesium implants have great potential in antitumor. According to the disease characteristics of ovarian cancer, we choose it to study the antitumor characteristics of biodegradable magnesium. We tested the anti-ovarian tumor properties of Mg through both in vivo and in vitro experiments. According to the optical in vivo imaging and relative tumor volume statistics of mice, high-purity Mg wires significantly inhibited the growth of SKOV3 cells in vivo. We find that the degradation products of Mg, Mg2+, and H2 significantly inhibit the growth of SKOV3 cells and promote their apoptosis. Our study suggests a good promise for the treatment of ovarian cancer.
中文翻译：
可生物降解的镁植入物抑制卵巢肿瘤的生长
上皮性卵巢癌的常见治疗方法是积极手术，然后进行铂类细胞毒性化学疗法。但是，残留的肿瘤细胞在术后复发期间对化学治疗药物具有抗性。卵巢癌的治疗需要突破和进展。近年来，由于镁合金在医疗器械领域的巨大潜力，其已被广泛开发为一种新型的可生物降解材料。从镁的降解产物来看，可生物降解的镁植入物具有巨大的抗肿瘤潜力。根据卵巢癌的疾病特征，我们选择它来研究可生物降解镁的抗肿瘤特性。我们通过体内和体外实验测试了Mg的抗卵巢肿瘤特性。根据小鼠的体内光学成像和相对肿瘤体积统计，高纯度的镁线显着抑制了SKOV3细胞的体内生长。我们发现镁，镁的降解产物2+和H 2显着抑制SKOV3细胞的生长并促进其凋亡。我们的研究表明卵巢癌的治疗前景良好。
更新日期：2020-02-03
中文翻译：
可生物降解的镁植入物抑制卵巢肿瘤的生长
上皮性卵巢癌的常见治疗方法是积极手术，然后进行铂类细胞毒性化学疗法。但是，残留的肿瘤细胞在术后复发期间对化学治疗药物具有抗性。卵巢癌的治疗需要突破和进展。近年来，由于镁合金在医疗器械领域的巨大潜力，其已被广泛开发为一种新型的可生物降解材料。从镁的降解产物来看，可生物降解的镁植入物具有巨大的抗肿瘤潜力。根据卵巢癌的疾病特征，我们选择它来研究可生物降解镁的抗肿瘤特性。我们通过体内和体外实验测试了Mg的抗卵巢肿瘤特性。根据小鼠的体内光学成像和相对肿瘤体积统计，高纯度的镁线显着抑制了SKOV3细胞的体内生长。我们发现镁，镁的降解产物2+和H 2显着抑制SKOV3细胞的生长并促进其凋亡。我们的研究表明卵巢癌的治疗前景良好。
京公网安备 11010802027423号