During pregnancy in humans, the physiology of the mother and foetus are finely regulated by many factors. Inappropriate regulation can result in pregnancy disorders, such as complications and foetal abnormalities. The early prediction or accurate diagnosis of related diseases is a concern of researchers. Liquid biopsy can be analysed for circulating cells, cell-free nucleic acids, and exosomes. Because exosomes can be detected in the peripheral blood of women in early pregnancy, these vesicles and their contents have become the focus of early prediction or diagnostic biomarker research on pregnancy complications and foetal developmental disorders. In this review, we focus on recent studies addressing the roles of peripheral blood exosomes and circulating miRNAs in pregnancy complications and in pregnancies with abnormal foetal developmental disorders, with particular attention paid to the potential application value of exosomes and circulating miRNAs as disease-specific biomarkers.

中文翻译：

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外泌体和循环微RNA在诊断妊娠并发症和胎儿异常中的临床应用。

在人类怀孕期间，母亲和胎儿的生理受到许多因素的良好调节。监管不当会导致怀孕失调，例如并发症和胎儿异常。相关疾病的早期预测或准确诊断是研究人员关注的问题。液体活检可以分析循环细胞，无细胞核酸和外泌体。由于可以在妊娠早期妇女的外周血中检测到外泌体，因此这些囊泡及其内容物已成为妊娠并发症和胎儿发育障碍的早期预测或诊断性生物标志物研究的重点。在这篇评论中