BACKGROUND Malignant fibrous neoplasms (MFN) of long bones are rare lesions. Moreover, the prognostic determinants of MFN of long bones have not been reported. This study aimed to present epidemiological data and analyse the prognostic factors for survival in patients with MFN. MATERIALS AND METHODS The Surveillance, Epidemiology, and End Results (SEER) programme database was used to screen patients with malignant fibrous neoplasms (MFN) of long bones from 1973 to 2015, with attention to fibrosarcoma, fibromyxosarcoma, periosteal fibrosarcoma and malignant fibrous histiocytoma. The prognostic values of overall survival (OS) and cancer-specific survival (CSS) were assessed using the Cox proportional hazards regression model with univariate and multivariate analyses. The Kaplan-Meier method was used to obtain OS and CSS curves. RESULTS A total of 237 cases were selected from the SEER database. Malignant fibrous histiocytoma was the most common form of lesion in long bones. Multivariate analysis revealed that independent predictors of OS included age, stage, tumour size and surgery. Age, stage, tumour size and surgery were also independent predictors of CSS. Additionally, the most significant prognostic factor was whether metastasis had occurred at the time of initial diagnosis. CONCLUSION Among patients with MFN of long bones, age (> 60 years), tumour size (> 10 cm), distant stage, and non-surgical treatment are factors for poor survival.

中文翻译：

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长骨恶性纤维性肿瘤：1973年至2015年的监测，流行病学和最终结果数据库分析。

背景技术长骨的恶性纤维瘤（MFN）是罕见的病变。此外，尚未报道长骨MFN的预后决定因素。这项研究旨在提供流行病学数据并分析MFN患者生存的预后因素。材料与方法监测，流行病学和最终结果（SEER）程序数据库用于筛查1973年至2015年长骨恶性纤维瘤（MFN）的患者，并注意纤维肉瘤，纤维肉瘤，骨膜纤维肉瘤和恶性纤维组织细胞瘤。使用Cox比例风险回归模型进行单变量和多变量分析，评估总体生存期（OS）和癌症特异性生存期（CSS）的预后价值。使用Kaplan-Meier方法获得OS和CSS曲线。结果从SEER数据库中总共选择了237例病例。恶性纤维组织细胞瘤是长骨中最常见的病变形式。多变量分析显示，OS的独立预测因子包括年龄，分期，肿瘤大小和手术。年龄，分期，肿瘤大小和手术也是CSS的独立预测因素。此外，最重要的预后因素是在最初诊断时是否已经发生转移。结论在长骨最惠国患者中，年龄（> 60岁），肿瘤大小（> 10 cm），远期分期和非手术治疗是生存不良的因素。肿瘤大小和手术。年龄，分期，肿瘤大小和手术也是CSS的独立预测因素。此外，最重要的预后因素是在初诊时是否已经发生转移。结论在长骨最惠国患者中，年龄（> 60岁），肿瘤大小（> 10 cm），远期分期和非手术治疗是生存不良的因素。肿瘤大小和手术。年龄，分期，肿瘤大小和手术也是CSS的独立预测因素。此外，最重要的预后因素是在最初诊断时是否已经发生转移。结论在长骨最惠国患者中，年龄（> 60岁），肿瘤大小（> 10 cm），远期分期和非手术治疗是生存不良的因素。