The current research study investigated the effect of 80 mg/kg b.wt./day curcumin (cur) against 50, 100, and 200 mg/kg copper oxychloride (COC) for 90 days induced testicular damage using histological, ultrastructural, and biochemical techniques. Histological and cellular abnormalities have been noted in seminiferous tubules of COC-treated group and treated group with Cur- and COC-treated group. The biochemical result showed that serum testosterone was significantly decreased in COC-treated rats and Cur COC-treated rats compared with the control groups. Testes copper content and malondialdehyde was increased, whereas the testes total antioxidant, manganese, ferrous, and zinc levels were decreased (p ≥ 0.05) compared to the control groups. In conclusion, the present work reported that the treatment of rats with 80 mg/kg body weight curcumin prior to treatment with COC did not mitigate the deleterious effects of COC and manifested no signs of protection.

中文翻译：

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氯氧化铜对成年白化病大鼠睾丸的损伤以及姜黄素可能在损伤中的作用。

当前的研究使用组织学，超微结构和生化反应研究了80 mg / kg b.wt./day姜黄素（cur）对50、100和200 mg / kg的氯氧化铜（COC）对90天诱发的睾丸损伤的影响技术。在COC治疗组和Cur治疗组和COC治疗组的生精小管中已注意到组织学和细胞异常。生化结果显示，与对照组相比，COC处理的大鼠和Cur COC处理的大鼠血清睾丸激素显着降低。与对照组相比，睾丸中的铜含量和丙二醛含量增加，而睾丸中的总抗氧化剂，锰，亚铁和锌含量降低（p≥0.05）。结论，