Abstract

Achieving effective hemostasis is significant to ensure the survival of the people with acute massive bleeding in the battlefield or daily life in pre-hospital care. In this work, modified cotton fabric with asymmetric wettability (Janus) was prepared using a fast and simple spray-coating strategy, where, one side of the fabric was sprayed with carboxymethyl chitosan solution to achieve hydrophilicity (0°) while the other side with hydrophobicity (152°) was built using paraffin. The hydrophilic surface could provide blood absorption and promote hemostasis, while the hydrophobic surface prevented the excessive blood absorption. The hemostatic efficiency of fabrics was tested in vitro and in vivo. Here, the carboxymethyl chitosan coated carboxymethylated cotton (CS-MCF) and Janus showed better hemostatic capacity than the cotton fabric (CF) in vitro with the lower blood clotting index. Furthermore, the Janus had better hemostatic performance than CF in rat liver animal model, and prolonged the survival time of the rats in carotid artery animal model. Therefore, Janus, with superior hemostatic efficiency over the cotton fabric, has a bright application prospect as hemostatic wound dressing.

Graphic abstract

摘要

有效的止血对于确保战场上或医院前护理中急性大出血患者的生存至关重要。在这项工作中，使用快速简便的喷涂策略制备了具有不对称润湿性（贾努斯）的改性棉织物，其中，织物的一侧喷涂有羧甲基壳聚糖溶液以达到亲水性（0°），而另一侧则采用使用石蜡建立疏水性（152°）。亲水表面可提供血液吸收并促进止血，而疏水表面可防止血液过度吸收。在体外和体内测试了织物的止血效率。这里，羧甲基壳聚糖包被的羧甲基化棉（CS-MCF）和Janus在体外具有比棉织物（CF）更好的止血能力，且凝血指数较低。此外，Janus在大鼠肝动物模型中具有比CF更好的止血性能，并延长了在颈动脉动物模型中大鼠的存活时间。因此，Janus具有比棉织物更好的止血效果，具有止血伤口敷料的广阔应用前景。

图形摘要