BACKGROUND AND AIMS Evidence have been supporting that histological activity of ulcerative colitis [UC] has relevance for the prediction of clinical outcomes in UC patients, such as clinical relapse. In this study, we aimed to compare two histological indexes - the continuous Geboes score [GS] and the Nancy index [NI] - regarding their definitions of histological remission and response, and to determine the ability of fecal calprotectin [FC] levels to discriminate between these histological statuses according to the NI. METHODS A large cohort of UC patients [N=422] that was previously enrolled in other studies was analyzed. RESULTS GS and NI were shown to be strongly correlated [correlation coefficient: 0.882, p < 0.001], indicating high accordance in the classification of patients as having/not having histological remission and response. FC levels moderately correlated with NI regarding these histological statuses [correlation coefficient: 0.481, p < 0.001], moderately predicted the absence of remission defined by NI > 0 [area under the curve (AUC) 0.667 (95% CI 0.609-0.724)], and were good predictors of the absence of histological response defined by NI > 1 [AUC 0.825 (95% CI 0.777-0.872)]. The optimal FC cut-offs determined to predict the NI-defined histological remission and response were 91 μg/g and 106 μg/g, when maximizing the negative predictive value [NPV]. CONCLUSIONS Due to the higher applicability of the NI, this study encourages the systematic use of this histological index to assess histological remission and response in UC patients.

中文翻译：

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Nancy指数与连续Geboes得分的比较：溃疡性结肠炎的组织学缓解和反应。

背景和目的已有证据支持溃疡性结肠炎[UC]的组织学活性与预测UC患者的临床结局如临床复发有关。在这项研究中，我们旨在比较两个组织学指标-连续吉布斯评分[GS]和南希指标[NI]-关于其组织学缓解和反应的定义，并确定粪便钙卫蛋白[FC]的水平区分能力根据NI在这些组织学状态之间进行区分。方法分析了以前参加过其他研究的一大批UC患者[N = 422]。结果显示GS和NI具有高度相关性[相关系数：0.882，p <0.001]，表明在具有或不具有组织学缓解和反应的患者分类中高度一致。在这些组织学状态中，FC水平与NI呈中等程度的相关性[相关系数：0.481，p <0.001]，中等预测了无NI> 0所定义的缓解[曲线下面积（AUC）0.667（95％CI 0.609-0.724）] ，并且可以很好地预测NI> 1 [AUC 0.825（95％CI 0.777-0.872）]所定义的组织学反应。当最大化阴性预测值[NPV]时，确定可预测NI定义的组织学缓解和反应的最佳FC临界值为91μg/ g和106μg/ g。结论由于NI的更高适用性，本研究鼓励系统地使用该组织学指标来评估UC患者的组织学缓解和反应。对NI> 0 [曲线下面积（AUC）0.667（95％CI 0.609-0.724）]定义的缓解没有适度的预测，并且对于NI> 1 [AUC 0.825（95 ％CI 0.777-0.872）]。当最大化阴性预测值[NPV]时，确定可预测NI定义的组织学缓解和反应的最佳FC临界值为91μg/ g和106μg/ g。结论由于NI的更高适用性，本研究鼓励系统地使用该组织学指标来评估UC患者的组织学缓解和反应。对NI> 0 [曲线下面积（AUC）0.667（95％CI 0.609-0.724）]定义的缓解没有适度的预测，并且对于NI> 1 [AUC 0.825（95 ％CI 0.777-0.872）]。当最大化阴性预测值[NPV]时，确定可预测NI定义的组织学缓解和反应的最佳FC临界值为91μg/ g和106μg/ g。结论由于NI的更高适用性，本研究鼓励系统地使用该组织学指标来评估UC患者的组织学缓解和反应。当最大化阴性预测值[NPV]时，确定可预测NI定义的组织学缓解和反应的最佳FC临界值为91μg/ g和106μg/ g。结论由于NI的更高适用性，本研究鼓励系统地使用该组织学指标来评估UC患者的组织学缓解和反应。当最大化阴性预测值[NPV]时，确定可预测NI定义的组织学缓解和反应的最佳FC临界值为91μg/ g和106μg/ g。结论由于NI的更高适用性，本研究鼓励系统地使用该组织学指标来评估UC患者的组织学缓解和反应。