Lugol chromoendoscopy is useful for the detection of early esophageal squamous cell cancer (ESCC). Multiple lugol‐voiding lesions (LVLs) on lugol chromoendoscopy are associated with a very high risk of multiple cancers arising in the esophagus. Due to the widespread use of narrow band image technology in many institutions, esophageal cancer without LVLs in the background esophagus is sometimes detected. This retrospective study aims to clarify the clinical characteristic of esophageal cancer without LVLs in the background esophagus. A total of 191 consecutive patients with 204 ESCCs had undergone endoscopic submucosal dissection (ESD) from 2011 and 2014. Amongst these lesions, the number of LVLs in the background esophagus per endoscopic view was counted excluding main lesion, and the grading was divided into no LVLs ESCC (nL‐ESCC) group and LVLs ESCC (L‐ESCC) group. This study evaluated the clinical characteristics and the cumulative incidence of metachronous ESCC after ESD in both groups. Thirty‐six patients with 36 lesions and 155 patients with 168 lesions were separated into the nL‐ESCC group and L‐ESCC group, respectively. On multivariate analysis, the nL‐ESCC group was found to be more common in females, who were non‐drinkers, or with erosive esophagitis. During follow‐up periods, the cumulative incidence of metachronous ESCC at 3‐years was 14.4% and 0.00% in the L‐ESCC and nL‐ESCC groups, respectively (P < 0.01). Our study showed that esophageal cancer without LVLs in the background esophagus was mostly occurred in females, who were non‐drinkers, or with erosive esophagitis, which are uncommon features of ESCC.

中文翻译：

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食管癌背景下无卢戈氏排尿病变的临床特征

Lugol 染色内镜检查可用于检测早期食管鳞状细胞癌 (ESCC)。lugol 色素内镜检查中的多处 lugol 排尿病变 (LVL) 与食道发生多种癌症的风险非常高。由于许多机构广泛使用窄带图像技术，有时会检测到背景食管中没有 LVL 的食管癌。这项回顾性研究旨在阐明背景食管中没有 LVL 的食管癌的临床特征。从 2011 年到 2014 年，共有 191 名连续的 204 个 ESCC 患者接受了内窥镜黏膜下剥离术 (ESD)。在这些病变中，每个内窥镜视图中的背景食管中的 LVL 数量被计算在内，不包括主要病变，分级分为无LVLs ESCC（nL-ESCC）组和LVLs ESCC（L-ESCC）组。本研究评估了两组 ESD 后异时性 ESCC 的临床特征和累积发生率。36 例 36 处病变和 155 例 168 处病变分别分为 nL-ESCC 组和 L-ESCC 组。在多变量分析中，发现 nL-ESCC 组在女性、不饮酒或患有糜烂性食管炎的女性中更常见。在随访期间，L-ESCC 和 nL-ESCC 组 3 年异时性 ESCC 的累积发生率分别为 14.4% 和 0.00%（P < 0.01）。我们的研究表明，在食管背景中没有 LVL 的食管癌主要发生在不饮酒或患有糜烂性食管炎的女性中。