A mechanistic description for how soluble protein cargos are sorted into distinct vesicle classes at the level of the trans-Golgi network (TGN) has remained elusive. In a recent study in Developmental Cell, Sundberg et al. reveal that sphingomyelin and a proteoglycan mediate lipoprotein lipase sorting in the TGN.

中文翻译：

---

脂蛋白脂肪酶分选：鞘磷脂和蛋白聚糖发挥作用。

关于如何在反式高尔基体网络（TGN）的水平上将可溶性蛋白货物分类为不同的囊泡类别的机制描述仍然难以捉摸。在对发育细胞的最新研究中，Sundberg等人。揭示鞘磷脂和蛋白聚糖介导TGN中的脂蛋白脂肪酶分选。