There is an urgent need for prognostic assays to predict progression to severe dengue infection, which is a major global threat. While the majority of symptomatic dengue patients experience an acute febrile illness, 5-20% progress to severe infection associated with significant morbidity and mortality. Early monitoring and administration of supportive care reduce mortality and clinically usable biomarkers to predict severe dengue are needed. Here, we review recent discoveries of gene sets, anti-dengue antibody properties, and inflammatory markers with potential utility as predictors of disease progression. Upon larger scale validation and development of affordable sample-to-answer technologies, some of these biomarkers may be utilized to develop the first prognostic assay for improving patient care and allocating healthcare resources more effectively in dengue endemic countries.

中文翻译：

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预测严重登革热的进展。

迫切需要进行预后分析以预测严重登革热感染的进展，这是一个主要的全球性威胁。虽然大多数有症状的登革热患者都患有急性发热性疾病，但5-20％的患者会发展为严重感染，并伴有明显的发病率和死亡率。早期监测和给予支持治疗可降低死亡率，因此需要临床可用的生物标志物来预测严重的登革热。在这里，我们回顾了基因集，抗登革热抗体特性和炎症标志物与疾病进展的预测指标的潜在发现的最新发现。经过大规模的验证并开发了价格合理的“样本到答案”技术，