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Neutrophils as emerging therapeutic targets.
Nature Reviews Drug Discovery ( IF 122.7 ) Pub Date : 2020-01-22 , DOI: 10.1038/s41573-019-0054-z Tamás Németh 1, 2 , Markus Sperandio 3 , Attila Mócsai 1
Nature Reviews Drug Discovery ( IF 122.7 ) Pub Date : 2020-01-22 , DOI: 10.1038/s41573-019-0054-z Tamás Németh 1, 2 , Markus Sperandio 3 , Attila Mócsai 1
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Neutrophils are the most abundant circulating leukocytes, being the first line of defence against bacterial and fungal infections. However, neutrophils also contribute to tissue damage during various autoimmune and inflammatory diseases, and play important roles in cancer progression. The intimate but complex involvement of neutrophils in various diseases makes them exciting targets for therapeutic intervention but also necessitates differentiation of beneficial responses from potentially detrimental side effects. A variety of approaches to therapeutically target neutrophils have emerged, including strategies to enhance, inhibit or restore neutrophil function, with several agents entering clinical trials. However, challenges and controversies in the field remain.
中文翻译：
中性粒细胞作为新兴的治疗靶点。
中性粒细胞是最丰富的循环白细胞，是抵御细菌和真菌感染的第一道防线。然而，中性粒细胞也会在各种自身免疫性疾病和炎症性疾病中造成组织损伤，并在癌症进展中发挥重要作用。中性粒细胞在各种疾病中的密切但复杂的参与使它们成为治疗干预的令人兴奋的目标，但也需要区分有益反应和潜在的有害副作用。已经出现了多种治疗性靶向中性粒细胞的方法，包括增强、抑制或恢复中性粒细胞功能的策略，其中几种药物进入了临床试验。然而，该领域的挑战和争议依然存在。
更新日期：2020-01-23
中文翻译：
中性粒细胞作为新兴的治疗靶点。
中性粒细胞是最丰富的循环白细胞，是抵御细菌和真菌感染的第一道防线。然而，中性粒细胞也会在各种自身免疫性疾病和炎症性疾病中造成组织损伤，并在癌症进展中发挥重要作用。中性粒细胞在各种疾病中的密切但复杂的参与使它们成为治疗干预的令人兴奋的目标，但也需要区分有益反应和潜在的有害副作用。已经出现了多种治疗性靶向中性粒细胞的方法，包括增强、抑制或恢复中性粒细胞功能的策略，其中几种药物进入了临床试验。然而，该领域的挑战和争议依然存在。
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