We thank Anil Pareek and colleagues for their suggestion that lower doses of chlorthalidone could reduce metabolic side-effects and improve the cost-effectiveness of a low-dose triple-pill strategy. Although moderate-to-high doses of thiazide-like diuretics have provided large reductions in cardiovascular events in previous trials, we agree there would be considerable clinical value in regimens with greater blood pressure lowering efficacy and fewer side-effects.

中文翻译：

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用6·25 mg氯噻酮优化TRIUMPH-作者的回复。

我们感谢阿尼尔·帕里克（Anil Pareek）及其同事的建议，即较低剂量的氯噻酮可以减少新陈代谢的副作用，并提高低剂量三药疗法的成本效益。尽管在以前的试验中，中等剂量至高剂量的噻嗪类利尿剂可大幅度降低心血管事件，但我们一致认为，降压疗效更高且副作用较少的治疗方案具有相当大的临床价值。