Linking prescription opioids and infectious diseases.,The Lancet Infectious Diseases

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Linking prescription opioids and infectious diseases.
The Lancet Infectious Diseases ( IF 36.4 ) Pub Date : 2020-01-22 , DOI: 10.1016/s1473-3099(19)30754-6
Asher J Schranz ₁ , Jessica A Meisner ₂

Affiliation

In Chicago, IL, USA, in the late 1970s, hospitalisations for infective endocarditis due to Pseudomonas aeruginosa began to increase among people who inject drugs. Once a rare occurrence, by 1980, P aeruginosa was the most common cause of endocarditis among people who inject drugs at Cook County Hospital (Chicago). It became clear, however, that P aeruginosa did not affect all individuals injecting drugs equally. It predominantly affected those injecting pentazocine, an opioid, and tripelennamine, an antihistamine (a combination known as T's and blues), which unlike heroin, were not boiled before injecting. This drug combination allowed P aeruginosa serotype O11 strains to survive, while inhibiting the growth of other P aeruginosa serotypes and Staphylococcus aureus, the latter being the main pathogen associated with infections in people using heroin. ^, In other words, the specific drugs and the way they were injected modulated the risk for a particular infection, with T's and blues serving as a selective medium for P aeruginosa O11.

中文翻译：

将处方阿片类药物与传染病联系起来。

1970年代后期，在美国伊利诺伊州芝加哥，因注射铜绿假单胞菌引起的感染性心内膜炎的住院治疗开始增加。到1980年，铜绿假单胞菌曾经是一种罕见的事件，是在库克县医院（芝加哥）注射毒品的人中最常见的心内膜炎原因。但是，很明显，铜绿假单胞菌并没有平等地影响所有注射毒品的人。它主要影响那些注射海洛因的海洛因，在注射前未煮沸，这些注射的药物有阿片类药物喷他佐辛和抗组胺药三苯胺（一种称为T和布鲁斯的混合物）。这种药物组合使铜绿假单胞菌血清型O11菌株得以存活，同时抑制其他铜绿假单胞菌血清型和金黄色葡萄球菌，后者是与使用海洛因的人感染有关的主要病原体。^，换句话说，他们被注射的特异性药物和方法调制的风险特定感染，与T的和用作选择性培养基蓝调铜绿假单胞菌O11。

更新日期：2020-03-27

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