Selective Oxyfunctionalisation Reactions Driven by Sulfite Oxidase‐Catalysed In Situ Generation of H2O2,ChemCatChem

当前位置： X-MOL 学术 › ChemCatChem › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Selective Oxyfunctionalisation Reactions Driven by Sulfite Oxidase‐Catalysed In Situ Generation of H2O2
ChemCatChem ( IF 3.8 ) Pub Date : 2020-01-22 , DOI: 10.1002/cctc.201902297
Morten M. C. H. Schie ₁ , Alexander T. Kaczmarek ₂ , Florian Tieves ₁ , Patricia Gomez de Santos ₃ , Caroline E. Paul ₁ , Isabel W. C. E. Arends ₄ , Miguel Alcalde ₃ , Günter Schwarz ₂ , Frank Hollmann ₁

Affiliation

H₂O₂ can be accepted by several peroxygenases as a clean oxidant, able to supply both the necessary electrons and oxygen atom at the same time. The biocatalysts, in turn, are able to catalyse an array of interesting oxygen insertion reactions at enantio‐ and regio‐selectivities hard to attain with classical chemical methods. The sensitivity of most peroxygenases towards H₂O₂, however, requires this oxidant to be generated in situ . Here, we suggest the application of (modified) sulfite oxidases to couple the oxidation of sulfites to the reduction of oxygen. This enables us to use calcium sulfite, an industrial waste product from scrubbing flue gases, as an electron donor to reduce oxygen. This will supply the required peroxide in a controlled manner and enables us to perform these challenging reactions at the expense of simple salts.

中文翻译：

亚硫酸氧化酶催化的H2O2原位生成驱动的选择性氧官能化反应

H ₂ O ₂可以被几种过氧化酶接受为清洁氧化剂，能够同时提供必要的电子和氧原子。反过来，生物催化剂能够以经典化学方法难以达到的对映和区域选择性催化一系列有趣的氧插入反应。但是，大多数过氧合酶对H ₂ O ₂的敏感性要求这种氧化剂在原位产生。。在此，我们建议应用（修饰的）亚硫酸盐氧化酶将亚硫酸盐的氧化与氧的还原偶联。这使我们能够使用亚硫酸钙（一种洗涤烟气的工业废品）作为电子供体，以减少氧气。这将以受控方式提供所需的过氧化物，并使我们能够以简单的盐为代价进行这些具有挑战性的反应。

更新日期：2020-01-22

点击分享查看原文

点击收藏

公开下载

阅读更多本刊最新论文本刊介绍/投稿指南11