Prenatal exposure to glufosinate ammonium disturbs gut microbiome and induces behavioral abnormalities in mice.,Journal of Hazardous Materials

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Prenatal exposure to glufosinate ammonium disturbs gut microbiome and induces behavioral abnormalities in mice.
Journal of Hazardous Materials ( IF 12.2 ) Pub Date : 2020-01-21 , DOI: 10.1016/j.jhazmat.2020.122152
Tianyu Dong ₁ , Quanquan Guan ₁ , Weiyue Hu ₁ , Mingzhi Zhang ₁ , Yuqing Zhang ₁ , Minjian Chen ₁ , Xinru Wang ₁ , Yankai Xia ₁

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Glufosinate ammonium (GLA) is a widely used organophosphate herbicide, which could be commonly detected in body fluids of both pregnant women and newborns. Existing evidences indicate that GLA has reproductive toxicity, while data concerning the effects of prenatal GLA exposure on neurodevelopment is rather limited. Here we employed a mouse model exposed to GLA prenatally. Reduced locomotor activity, impaired memory formation and autism-like behaviors were observed in the treatment group. Marked alteration in gut microbiome of the treatment offspring mice could be found at 4th week, and seemed to recover over time. Fecal metabolomics analysis indicated remarkable changes in microbiome-related metabolism in the treatment group, which could be the cause of behavioral abnormality in mice. Present study suggested that prenatal exposure to GLA disturbed gut microbiome and metabolism, and thereby induced behavioral abnormalities in mice.

中文翻译：

产前暴露于草铵膦的铵盐会干扰肠道微生物组，并诱发小鼠行为异常。

草铵膦（GLA）是一种广泛使用的有机磷酸酯除草剂，通常在孕妇和新生儿的体液中都可以检测到。现有证据表明，GLA具有生殖毒性，而有关产前GLA暴露对神经发育影响的数据非常有限。在这里，我们采用了产前暴露于GLA的小鼠模型。在治疗组中观察到运动能力降低，记忆形成受损和自闭症样行为。治疗后代小鼠的肠道微生物组明显改变，可在第4周发现，并且随着时间的推移似乎会恢复。粪便代谢组学分析表明，治疗组中微生物组相关的代谢发生了显着变化，这可能是小鼠行为异常的原因。

更新日期：2020-01-22

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