Pemphigus is an autoimmune bullous disease characterized by IgG production against desmogleins. The major sites of autoantibody production are thought to be lymph nodes, spleen, and bone marrow. Previously, it has been suggested that autoreactive B cells might exist in the skin lesions in pemphigus and produce autoantibodies. In their report, Zhou et al. expanded their previous studies and reported that ectopic lymphoid-like structures were found in pemphigus skin lesions, wherein B-cell differentiation and lesional B-cell expansion might progress. This finding provides novel insights into B-cell biology in pemphigus.

中文翻译：

---

在天疱疮中皮肤病变中自身抗体的局部产生是否相关？

天疱疮是一种自身免疫性大疱性疾病，其特征在于产生针对桥粒芯蛋白的IgG。自身抗体产生的主要部位被认为是淋巴结，脾脏和骨髓。以前，已经有人提出天疱疮的皮肤病变中可能存在自身反应性B细胞并产生自身抗体。在他们的报告中，Zhou等。扩展了他们先前的研究，并报道在天疱疮皮肤病变中发现了异位的类淋巴样结构，其中B细胞分化和病变性B细胞扩张可能会进展。这一发现为天疱疮的B细胞生物学提供了新颖的见解。