The development of innovative bio-based skin care products has received an increase attention in the latter years. In the present work, the synthesis of original active principle ingredients based ionic liquids (ILs) with cholinium cation and vitamins B anions followed by their incorporation in bacterial nanocellulose (BC) membranes for topical applications is reported. Three ILs, namely cholinium nicotinate [Ch][B3], cholinium pantothenate [Ch][B5] and cholinium pyridoxylate [Ch][B6], were synthesized through a metathesis reaction and their structure characterized in detail. Thermal analysis confirmed their denomination as ILs and their high thermal resistance. The solubility of these ILs was higher than their vitamin precursors, especially in the case of [Ch][B3] whose solubility increased 30.6-fold enhancing the bioavailability of this vitamin. The incorporation of ILs in BC led to transparent and homogeneous membranes stable up to 190 °C. ILs acted as plasticizers reducing BC brittleness that facilitated their application on irregular skin regions. Moreover, the re-hydration ability of BC-ILs membranes was improved 2.9 to 4.8-fold in comparison to BC, ensuring adequate hydration for ILs release, while the release of ILs in buffer solutions was more complete and faster than the release of vitamins. Finally, BC-ILs were proven not cytotoxic to skin epithelial cells and thus are suitable materials for skin care applications.

近年来，基于生物的新型皮肤护理产品的开发受到越来越多的关注。在目前的工作中，已报道了合成具有胆碱阳离子和维生素B阴离子的基于活性成分的原始离子液体（ILs），然后将其掺入细菌纳米纤维素（BC）膜中以进行局部应用的报道。通过易位反应合成了烟酸胆碱[Ch] [B3]，泛酸胆碱[Ch] [B5]和吡啶氧基化胆碱[Ch] [B6]三个IL，并对其结构进行了详细表征。热分析证实了它们的名称为IL，并且具有很高的热阻。这些IL的溶解度高于其维生素前体，特别是在[Ch] [B3]的情况下，其溶解度增加了30.6倍，从而增强了这种维生素的生物利用度。IL在BC中的掺入导致透明和均匀的膜在高达190°C的温度下稳定。IL充当增塑剂，可降低BC脆性，从而促进其在不规则皮肤区域的应用。此外，与BC相比，BC-ILs膜的再水合能力提高了2.9到4.8倍，确保了ILs释放的足够水合作用，而缓冲液中ILs的释放比维生素的释放更完全，更快。最后，事实证明，BC-ILs对皮肤上皮细胞无细胞毒性，因此是适用于皮肤护理的材料。与BC相比，BC-ILs膜的再水合能力提高了2.9到4.8倍，确保了ILs释放的足够水合作用，而缓冲液中ILs的释放比维生素的释放更完全，更快。最后，事实证明，BC-ILs对皮肤上皮细胞无细胞毒性，因此是适用于皮肤护理的材料。与BC相比，BC-ILs膜的再水合能力提高了2.9到4.8倍，确保了ILs释放的足够水合作用，而缓冲液中ILs的释放比维生素的释放更完全，更快。最后，事实证明，BC-ILs对皮肤上皮细胞无细胞毒性，因此是适用于皮肤护理的材料。