The mechanisms of melanoma metastasis have been the subject of extensive research for decades. Improved diagnostic and therapeutic strategies are of increasing importance for the treatment of melanoma due to its high burden of mortality in the advanced stages of the disease. Intercellular communication is a critical event for the progression of cancer. Collective evidence suggests that exosomes, small extracellular membrane vesicles released by the cells, are important facilitators of intercellular communication between the cells and the surrounding environment. Although the emerging field of exosomes is rapidly gaining traction in the scientific community, there is limited knowledge regarding the role of exosomes in melanoma. This review discusses the multifaceted role of melanoma-derived exosomes in promoting the process of metastasis by modulating the invasive and angiogenic capacity of malignant cells. The future implications of exosome research and the therapeutic potential of exosomes are also discussed.

中文翻译：

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外泌体在黑色素瘤转移和进展中的作用。

数十年来，黑色素瘤转移的机制一直是广泛研究的主题。改善的诊断和治疗策略对黑素瘤的治疗越来越重要，因为它在疾病晚期具有很高的死亡率。细胞间通讯是癌症发展的关键事件。集体证据表明，外泌体是由细胞释放的小的细胞外膜囊泡，是细胞与周围环境之间的细胞间通讯的重要促进剂。尽管外来体的新兴领域在科学界迅速受到关注，但是关于外来体在黑色素瘤中的作用的知识仍然有限。这篇综述讨论了黑素瘤来源的外来体在通过调节恶性细胞的侵袭和血管生成能力来促进转移过程中的多重作用。还讨论了外泌体研究的未来意义和外泌体的治疗潜力。