Celiac disease (CD) is a systematic immune-mediated enteropathy induced in the most genetically predisposed people by exposure to prolamin proteins. The only effective strategy for inhibiting CD is a lifelong exclusion of gluten from patient’s diet; however, adherence to a gluten-free diet (GFD) could be difficult for them. Because of this challenge, there is a demand for novel therapies. The utilization of probiotics in CD patient’s diets has been proposed as a novel therapy for reducing CD symptoms. Probiotic strains can suppress the gliadin toxicity through some probable mechanisms such as enzymatic hydrolysis of toxic peptides derived from gliadin. The present review describes the recent scientific researches about mechanisms of suppressing gliadin by probiotics.

腹腔疾病（CD）是遗传性最易感人群中由于暴露于谷醇溶蛋白而引起的系统性免疫介导的肠病。抑制CD的唯一有效策略是终生排除患者饮食中的面筋。但是，对他们而言，坚持无麸质饮食（GFD）可能很困难。由于这一挑战，需要新颖的疗法。已经提出在CD患者饮食中使用益生菌是减少CD症状的新疗法。益生菌菌株可以通过某些可能的机制抑制麦醇溶蛋白的毒性，例如酶水解麦醇溶蛋白衍生的有毒肽。本综述描述了有关益生菌抑制麦醇溶蛋白机制的最新科学研究。