Secreted frizzled-related protein 5 (Sfrp5) primarily acts in combination with wingless-type family member 5a (Wnt5a), to inhibits chronic inflammation and repress atherosclerosis and other metabolic disorders. Epicardial adipose tissue (EAT), surrounding the heart and coronary arteries, has been found to be highly related to the progression of coronary artery disease through adipokines production. However, little is known about EAT-derived Sfrp5 and Wnt5a in humans. We aimed to investigate whether the EAT-derived Sfrp5/Wnt5a levels are altered in patients with CAD. Fifty-eight patients with CAD and 29 patients without CAD who underwent cardiac surgery were enrolled. Serum samples and paired adipose biopsies from EAT and subcutaneous adipose tissue (SAT) were collected, and Sfrp5 and Wnt5a levels were detected. Correlation and multivariate regression analyses were performed to determine the relationship between Sfrp5/Wnt5a expression and CAD and other clinical risk factors. According to the results, the CAD group had lower Sfrp5 and higher Wnt5a levels in EAT and serum (all p < 0.05). Serum Sfrp5 levels were significantly lower in CAD patients with impaired myocardial function. EAT Sfrp5 mRNA levels and serum Sfrp5 levels were both negatively associated with the presence of CAD, after adjustment for known biomarkers, EAT mRNA and serum Wnt5a levels correlated positively with the presence of CAD. Thus, we concluded that low Sfrp5 and high Wnt5a levels are associated with the presence of CAD, independent of other conventional risk factors.

中文翻译：

---

Sfrp5 / Wnt5a在人心外膜脂肪组织中的表达及其与冠心病的关系。

分泌的卷曲相关蛋白5（Sfrp5）主要与无翅型家族成员5a（Wnt5a）结合使用，以抑制慢性炎症并抑制动脉粥样硬化和其他代谢性疾病。已经发现，围绕心脏和冠状动脉的心外膜脂肪组织（EAT）与脂肪因子的产生与冠状动脉疾病的进展高度相关。但是，关于人类中EAT衍生的Sfrp5和Wnt5a知之甚少。我们旨在调查CAD患者中EAT衍生的Sfrp5 / Wnt5a水平是否改变。入选了接受心脏手术的58例CAD患者和29例非CAD患者。收集来自EAT和皮下脂肪组织（SAT）的血清样本和成对的脂肪活检，并检测Sfrp5和Wnt5a的水平。进行相关和多元回归分析，以确定Sfrp5 / Wnt5a表达与CAD和其他临床危险因素之间的关系。根据结果​​，CAD组的EAT和血清中的Sfrp5较低，而Wnt5a较高（所有p <0.05）。患有心肌功能受损的CAD患者的血清Sfrp5水平显着降低。饮食中的Sfrp5 mRNA水平和血清Sfrp5水平均与CAD的存在负相关，在对已知生物标志物进行调整后，EAT mRNA和血清Wnt5a水平与CAD的存在呈正相关。因此，我们得出结论，低Sfrp5和高Wnt5a水平与CAD的存在有关，而与其他常规风险因素无关。