Abstract We present the linear and nonlinear resonance ejection of high mass-to-charge (m/z) ratio of protein ions with charge detection rectilinear ion trap mass spectrometer (CD RIT-MS). The measurements of ejected high mass ions with dipolar resonance ejection in the presence of high order fields are demonstrated. With linear resonance ejection, it was found the measured ion number could be enhanced by a factor of 3–5 as compared to that with boundary ejection. With nonlinear resonance ejection (with high order fields), e.g. a positive octopolar field, the ion number can be enhanced by a factor of 4–6 as compared to that with boundary ejection. Mass resolution is slightly improved with nonlinear resonance ejection (∼1.4 for cytochrome C ions) as compared to linear resonance ejection and about a factor of 5 improvements as compared to boundary ejection. In addition, when analyzing heavier bovine serum albumin (BSA) ions, it was observed that co-occurrence of boundary and resonance ejection was prominent with respect to m/z values, iso-β points, and auxiliary AC resonance amplitude where the ejection was below an octopolar field point of βu = 0.70.

中文翻译：

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使用电荷检测直线离子阱质谱仪进行高质量离子的线性和非线性共振喷射

摘要 我们介绍了使用电荷检测直线离子阱质谱仪 (CD RIT-MS) 对蛋白质离子的高质荷比 (m/z) 进行线性和非线性共振喷射。演示了在高阶场存在的情况下用偶极共振喷射测量喷射的高质量离子。通过线性共振喷射，发现与边界喷射相比，测量的离子数可以提高 3-5 倍。使用非线性共振喷射（具有高阶场），例如正八极场，与边界喷射相比，离子数可以提高 4-6 倍。非线性共振喷射（~1. 4（对于细胞色素 C 离子）与线性共振喷射相比，与边界喷射相比提高了约 5 倍。此外，在分析较重的牛血清白蛋白 (BSA) 离子时，观察到边界和共振喷射的共现在 m/z 值、iso-β 点和辅助 AC 共振振幅方面是突出的，其中喷射是低于 βu = 0.70 的八极场点。