Members of the nuclear receptor (NR) superfamily orchestrate cellular processes that can impact on numerous cancer hallmarks. NR activity plays important roles in the tumor microenvironment by controlling inflammation and immune responses. We summarize recent insights into the diverse mechanisms by which NR activity can control tumor inflammation, the roles of different NRs in modulating tumor immunity, and the biological features of immune cells that express specific NRs in the context of cancer. NR-dependent alterations in tumor inflammation and immunity may be amenable to pharmacological manipulation and offer new clues regarding the development of novel cancer therapeutic regimens.

中文翻译：

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癌症炎症和免疫中的核受体。

核受体（NR）超家族成员精心策划可能影响众多癌症标志的细胞过程。NR活性通过控制炎症和免疫反应在肿瘤微环境中起重要作用。我们总结了对NR活性可以控制肿瘤炎症的各种机制，不同NRs在调节肿瘤免疫中的作用以及在癌症背景下表达特定NRs的免疫细胞生物学特征的最新见解。NR依赖性的肿瘤炎症和免疫改变可能适合药理学操作，并为新型癌症治疗方案的发展提供了新的线索。