Neurodegenerative diseases like Alzheimer's disease and Parkinson's disease are characterized pathologically by aberrant protein accumulation, such as Aβ or α-synuclein deposition. In this issue of Neuron, Bassil et al. (2020) observed an exacerbation of α-syn pathology in the presence of Aβ plaques in vivo, with comorbid pathologies associated with greater neurodegeneration.

中文翻译：

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Aβ将α置于突触核蛋白中。

神经退行性疾病，例如阿尔茨海默氏病和帕金森氏病，在病理学上以异常的蛋白质积累为特征，例如Aβ或α-突触核蛋白沉积。在本期《神经元》中，Bassil等人。（2020）等人观察到，在体内存在Aβ斑块的情况下，α-syn病理的恶化，伴随着与更大的神经变性相关的合并病。