Radial glia-like neural stem cells (RGLs) in the dentate gyrus subregion of the hippocampus give rise to dentate granule cells (DGCs) and astrocytes throughout life, a process referred to as adult hippocampal neurogenesis. Adult hippocampal neurogenesis is sensitive to experiences, suggesting that it may represent an adaptive mechanism by which hippocampal circuitry is modified in response to environmental demands. Experiential information is conveyed to RGLs, progenitors, and adult-born DGCs via the neurogenic niche that is composed of diverse cell types, extracellular matrix, and afferents. Understanding how the niche performs its functions may guide strategies to maintain its health span and provide a permissive milieu for neurogenesis. Here, we first discuss representative contributions of niche cell types to regulation of neural stem cell (NSC) homeostasis and maturation of adult-born DGCs. We then consider mechanisms by which the activity of multiple niche cell types may be coordinated to communicate signals to NSCs. Finally, we speculate how NSCs integrate niche-derived signals to govern their regulation.

中文翻译：

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成人海马神经源性利基市场中的交流，相声和信号整合。

海马齿状回亚区域中的放射状胶质样神经干细胞（RGL）在整个生命过程中产生齿状颗粒细胞（DGC）和星形胶质细胞，这一过程称为成年海马神经发生。成人海马神经发生对经验很敏感，这表明它可能代表一种适应性机制，通过该机制海马回路可响应环境需求而被修饰。经验信息通过神经源利基传递给RGL，祖细胞和成年DGC，神经源利基由多种细胞类型，细胞外基质和传入分子组成。了解小生境如何发挥其功能可能会指导维持其健康期并为神经发生提供宽松环境的策略。这里，我们首先讨论利基细胞类型对神经干细胞（NSC）稳态和成年DGC的成熟调节的代表性贡献。然后，我们考虑可以协调多种小生境细胞类型活动以将信号传递给NSC的机制。最后，我们推测NSC如何整合利基衍生信号来控制其调控。