Rieske iron-sulfur protein (RISP) is a catalytic subunit of the complex III in the mitochondrial electron transport chain. Studies for years have revealed that RISP is essential for the generation of intracellular reactive oxygen species (ROS) via delicate signaling pathways associated with many important molecules such as protein kinase C-ε, NADPH oxidase, and ryanodine receptors. More significantly, mitochondrial RISP-mediated ROS production has been implicated in the development of hypoxic pulmonary vasoconstriction, leading to pulmonary hypertension, right heart failure, and death. Investigations have also shown the involvement of RISP in ROS-dependent cardiac ischemic/reperfusion injuries. Further research may provide novel and valuable information that can not only enhance our understanding of the functional roles of RISP and the underlying molecular mechanisms in the pulmonary vasculature and other systems, but also elucidate whether RISP targeting can act as preventative and restorative therapies against pulmonary hypertension, cardiac diseases, and other disorders.

中文翻译：

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肺动脉平滑肌中的线粒体Rieske铁硫蛋白：肺动脉高压中的关键主要信号分子。

里斯克铁硫蛋白（RISP）是线粒体电子传输链中复合物III的催化亚基。多年的研究表明，RISP对于通过与许多重要分子（例如蛋白激酶C-ε，NADPH氧化酶和ryanodine受体）相关的精细信号通路生成细胞内活性氧（ROS）至关重要。更重要的是，线粒体RISP介导的ROS产生与低氧性肺血管收缩的发展有关，导致肺动脉高压，右心衰竭和死亡。研究还表明，RISP参与了ROS依赖的心脏缺血/再灌注损伤。