RNA activation in insects: The targeted activation of endogenous and exogenous genes.,Insect Biochemistry and Molecular Biology

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RNA activation in insects: The targeted activation of endogenous and exogenous genes.
Insect Biochemistry and Molecular Biology ( IF 3.2 ) Pub Date : 2020-01-21 , DOI: 10.1016/j.ibmb.2020.103325
Lachlan De Hayr ₁ , Sultan Asad ₁ , Mazhar Hussain ₁ , Sassan Asgari ₁

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RNA activation (RNAa) is a newly emerging area of research in which dsRNA targeting promoter regions can induce the expression of the target gene. Although still in its infancy, it is already having significant impacts in several research areas in particular as cancer therapeutics. So far, the scope of RNAa has been limited to mammals and Caenorhabditis elegans with no indication of its prevalence in insects. In this study, we aimed to demonstrate the presence of RNAa in the insect dengue vector Aedes aegypti. Furthermore, we looked to uncover some details surrounding the involvement of host factors in order to present this as a new technique for insect research. The outcomes of this study provide new opportunities to further research into arthropod-borne diseases and insect biology in the same way as RNA interference.

中文翻译：

昆虫中的RNA激活：内源性和外源性基因的靶向激活。

RNA激活（RNAa）是一个新兴的研究领域，其中靶向启动子区域的dsRNA可以诱导靶基因的表达。尽管仍处于起步阶段，但它已经在多个研究领域产生了重大影响，尤其是作为癌症治疗剂。到目前为止，RNAa的范围仅限于哺乳动物和秀丽隐杆线虫，没有迹象表明其在昆虫中的流行。在这项研究中，我们旨在证明在昆虫登革热媒介埃及伊蚊中存在RNAa。此外，我们希望揭示宿主因素参与的一些细节，以便将其作为昆虫研究的新技术。这项研究的结果提供了新的机会，以与RNA干扰相同的方式进一步研究节肢动物传播的疾病和昆虫生物学。

更新日期：2020-01-22

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