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Factors associated with in-hospital mortality from community-acquired pneumonia in Portugal: 2000-2014.
BMC Pulmonary Medicine ( IF 2.6 ) Pub Date : 2020-01-21 , DOI: 10.1186/s12890-019-1045-x
Ezequiel Pessoa 1 , Cristina Bárbara 2, 3, 4 , Laura Viegas 1 , Andreia Costa 1, 3 , Matilde Rosa 3 , Paulo Nogueira 3, 5
Affiliation  

BACKGROUND Community-acquired pneumonia (CAP) is one of the leading causes of morbidity and mortality worldwide, often leading to hospital admissions. In Portugal, the factors associated with in-hospital mortality due to CAP are not fully documented. The aim of this study was to characterize the trends of CAP hospitalization in all age groups and the factors associated with their mortality between 2000 and 2014. METHODS We conducted a cross-sectional study using CAP hospitalization data in all age groups, in Portugal Mainland. Logistic regression was used to identify the factors associated with in-hospital mortality. RESULTS Between 2001 and 2011, CAP hospitalization rate increased from 2.8 to 4.3 per 1000 population. Hospitalization rates were higher in the extreme ages ( ≤ 4 and  ≥ 75 years). However, a decrease in the hospitalization rate and its mortality was observed, in the younger ages. A total of 548,699 hospitalization CAP episodes, between 2000 and 2014, were analyzed, with male (56.2%) and elderly ≥65 years (91.7%) predominance, resulting in 101,740 deaths (18.5%). Men had a significantly lower mean age (64.3 ± 26.4 years versus 67.9 ± 27.5 years; p < 0.001). During the studied 15 years, there was an increase of 45.2% in the number of annual hospitalizations, concomitant with the admission increase of individuals aged over 75 years. Since 2012 a decrease in hospitalizations and associated deaths were detected. The increase in age represented a progressive and significant rise in the probability of death, except for the age group 1-4 years. The age group ≥85 years old (Adjusted OR = 124.256; 95%CI: 97.838-157.807) and males (Adjusted OR = 1.261; 95%CI: 1.243-1.280) were significantly associated with death risk for CAP hospitalization. After 2010, this risk decreased (Adjusted OR = 0.961; 95%CI: 0.940-0.982). The main factors affecting mortality were age, sex, unemployment rate, number of performed procedures and admission quinquennia. CONCLUSIONS Despite a trend of decrease in CAP hospitalizations and associated death since 2012, the numbers of in-hospital mortality showed, in the 15 years under analysis, an overall increase over time, mainly associated with age, in particular very old people ( ≥ 75 years), males and a higher parish unemployment rate. Therefore, the implementation of CAP preventive measures should be reinforced in these vulnerable groups.

中文翻译:

葡萄牙社区获得性肺炎与院内死亡率相关的因素:2000-2014年。

背景技术社区获得性肺炎(CAP)是全球发病率和死亡率的主要原因之一,常常导致入院。在葡萄牙,与CAP导致的院内死亡相关的因素尚未得到充分记录。这项研究的目的是描述2000年至2014年间所有年龄段CAP住院的趋势及其相关因素。方法我们使用葡萄牙大陆所有年龄段的CAP住院数据进行了横断面研究。使用逻辑回归分析确定与院内死亡率相关的因素。结果2001年至2011年,CAP住院率从每千人2.8例增加到4.3例。在极端年龄(≤4和≥75岁)中,住院率更高。然而,在较年轻的年龄中,观察到住院率及其死亡率的下降。在2000年至2014年之间,共分析了548,699例CAP住院病例,其中男性(56.2%)和≥65岁的老人(91.7%)为主导,导致101,740例死亡(18.5%)。男性的平均年龄明显较低(64.3±26.4岁与67.9±27.5岁; p <0.001)。在研究的15年中,每年住院的次数增加了45.2%,同时年龄在75岁以上的人的入院人数也随之增加。自2012年以来,发现住院人数和相关死亡人数有所下降。年龄的增加表示死亡的可能性逐渐增加,并且显着增加,但1-4岁年龄段除外。年龄≥85岁的年龄组(校正后的OR = 124.256; 95%CI:97.838-157。807)和男性(校正OR = 1.261; 95%CI:1.243-1.280)与CAP住院的死亡风险显着相关。2010年之后,这种风险降低了(调整后的OR = 0.961; 95%CI:0.940-0.982)。影响死亡率的主要因素是年龄,性别,失业率,执行的手术次数和入院昆仑症。结论尽管自2012年以来CAP住院人数和相关死亡人数呈下降趋势,但在所分析的15年中,医院内死亡人数总体上随时间增加,主要与年龄有关,尤其是老年人(≥75岁)年),男性和较高的教区失业率。因此,这些弱势群体应加强CAP预防措施的实施。280)与CAP住院的死亡风险显着相关。2010年之后,这种风险降低了(调整后的OR = 0.961; 95%CI:0.940-0.982)。影响死亡率的主要因素是年龄,性别,失业率,执行的手术次数和入院昆仑症。结论尽管自2012年以来CAP住院人数和相关死亡人数呈下降趋势,但在所分析的15年中,医院内死亡人数总体上随时间增加,主要与年龄有关,尤其是老年人(≥75岁)年),男性和较高的教区失业率。因此,这些弱势群体应加强CAP预防措施的实施。280)与CAP住院的死亡风险显着相关。2010年之后,这种风险降低了(调整后的OR = 0.961; 95%CI:0.940-0.982)。影响死亡率的主要因素是年龄,性别,失业率,执行的手术次数和入院昆仑症。结论尽管自2012年以来CAP住院人数和相关死亡人数呈下降趋势,但在所分析的15年中,医院内死亡人数总体上随时间增加,主要与年龄有关,尤其是老年人(≥75岁)年),男性和较高的教区失业率。因此,这些弱势群体应加强CAP预防措施的实施。进行的手术次数和入院昆仑尼娅。结论尽管自2012年以来CAP住院人数和相关死亡人数呈下降趋势,但在所分析的15年中,医院内死亡人数总体上随时间增加,主要与年龄有关,尤其是老年人(≥75岁)年),男性和较高的教区失业率。因此,这些弱势群体应加强CAP预防措施的实施。执行的手术次数和入院昆仑尼娅。结论尽管自2012年以来CAP住院人数和相关死亡人数呈下降趋势,但在所分析的15年中,医院内死亡人数总体上随时间增加,主要与年龄有关,尤其是老年人(≥75岁)年),男性和较高的教区失业率。因此,这些弱势群体应加强CAP预防措施的实施。男性和较高的教区失业率。因此,这些弱势群体应加强CAP预防措施的实施。男性和较高的教区失业率。因此,这些弱势群体应加强CAP预防措施的实施。
更新日期:2020-01-22
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