BACKGROUND Obesity has been longitudinally associated with depression but only few studies take a life course approach. This longitudinal study investigates whether being overweight or obese at age 8 and 13 years is associated with depressive symptoms more than 60 years later and whether this association is independent of late-life body mass index (BMI). We also investigated the association of being overweight/obese at age 8 or 13 years with ever having major depressive disorder (lifetime MDD). METHOD This analysis is based on a sub-sample of 889 AGES-Reykjavik participants with measured BMI data from early life. Late-life depressive symptoms were measured with the Geriatric Depression Scale (GDS) and lifetime MDD was assessed at late-life using the Mini International Neuropsychiatric Interview. Logistic regression analysis was used to estimate the relationships between BMI (continuous and categorical) at age 8 or 13 years, and late-life depressive symptoms (measured as GDS ≥ 5) or lifetime MDD, adjusted for sex, education, physical activity, smoking status and alcohol use. In a separate model, additional adjustments were made for late-life BMI. RESULTS One hundred and one subjects (11%) had depressive symptoms at late-life (GDS ≥ 5), and 39 subjects (4.4%) had lifetime MDD. Being overweight or obese at age 8 or 13 years was not associated with higher depressive symptoms during late-life, irrespective of late-life BMI. Being overweight or obese at age 8 years, but not age 13 years was associated with an increased risk of lifetime MDD (Odds Ratio (OR) (95% confidence interval [CI]) for age 8 = 4.03[1.16-13.96]P = 0.03 and age 13 = 2.65[0.69-10.26] P = 0.16, respectively). CONCLUSION Being overweight in childhood was associated with increased odds of lifetime MDD, although the magnitude of the risk is uncertain given the small numbers of participants with lifetime MDD. No clear association was observed between childhood and adolescent overweight/obesity and late-life depressive symptoms irrespective of late life BMI.

中文翻译：

---

儿童期超重和肥胖以及一生中患抑郁症的风险。


背景 肥胖与抑郁症存在纵向相关性，但只有少数研究采用生命全程方法。这项纵向研究调查了 8 岁和 13 岁时超重或肥胖是否与 60 多年后的抑郁症状相关，以及这种关联是否独立于晚年体重指数 (BMI)。我们还调查了 8 岁或 13 岁时超重/肥胖与曾经患有重度抑郁症（终生 MDD）的关系。方法 该分析基于 889 名 AGES-Reykjavik 参与者的子样本，并测量了他们早期生活的 BMI 数据。使用老年抑郁量表 (GDS) 测量晚年抑郁症状，并使用小型国际神经精神病学访谈在晚年评估终生 MDD。 Logistic 回归分析用于估计 8 岁或 13 岁时的 BMI（连续和分类）与晚年抑郁症状（以 GDS ≥ 5 衡量）或终生 MDD 之间的关系，并根据性别、教育程度、体力活动、吸烟情况进行调整状况和饮酒情况。在一个单独的模型中，对晚年体重指数进行了额外的调整。结果 101 名受试者 (11%) 在晚年有抑郁症状 (GDS ≥ 5)，39 名受试者 (4.4%) 患有终生 MDD。无论晚年体重指数如何，8 岁或 13 岁时超重或肥胖与晚年抑郁症状加重无关。 8 岁时超重或肥胖（而非 13 岁时）与终生 MDD 风险增加相关（优势比 (OR)（95% 置信区间 [CI]），8 岁时 = 4.03[1.16-13.96]P = 0.03 和 13 岁 = 2.65[0.69-10.26] P = 0.16，分别）。 结论 儿童期超重与终生 MDD 的几率增加相关，尽管考虑到终生 MDD 的参与者数量较少，风险的大小尚不确定。无论晚年体重指数如何，儿童和青少年超重/肥胖与晚年抑郁症状之间没有观察到明显的关联。