BACKGROUND This study investigated the dose-response relationship between alcohol consumption and CVD incidence, conducting a meta-analysis of studies focusing on residents from local communities. Further, we examined whether light to moderate alcohol consumption had a protective effect on CVD incidence through a sub-group analysis. METHODS This study conducted a meta-analysis of the relationship between alcohol consumption and CVD incidence, selecting journals published up to December 2017. The alcohol consumption level was classified into non-consumers, light (0.01-10.0 g/day), light to moderate (10.1-20.0 g/day), moderate (20.1-40.0 g/day), moderate to high (40.1-60.0 g/day), and high (> 60.0 g/day) groups. The sub-group analysis was conducted according to the number of comorbidities and age. RESULTS Seven articles were selected in total for the meta-analysis. The mean Newcastle-Ottawa scale score was 8.14 points, suggesting studies were of high quality. There was a J-shaped dose-response relationship between alcohol consumption level and CVD incidence only in men. In general, light to moderate and moderate consumption lowered CVD incidence (Relative risk (RR) [95% confidence interval (CI)] was 0.68 [0.57-0.81] and 0.72 [0.58-0.90], respectively). In men with 3-4 comorbidities, there were no protective effects of light to moderate and moderate consumption on CVD incidence. In either groups of only men or men and women there were protective effects of light to moderate and moderate consumption on CVD incidence only in those aged between 41 and 65. DISCUSSION We found that light to moderate and moderate alcohol consumption had a protective effect on CVD incidence, there was no protective effect either in those with at least three comorbidities or people aged 40 or younger. CONCLUSIONS We conclude that not all local community residents experience a protective effect of light to moderate consumption on CVD incidence. As such, it is necessary to recommend a moderate amount of drinking or less for each individual.

中文翻译：

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饮酒对心血管疾病的保护作用是真的吗？对在社区环境中进行的研究进行系统的回顾和荟萃分析。

背景技术这项研究调查了饮酒量与CVD发病率之间的剂量反应关系，并进行了以本地居民为研究对象的荟萃分析。此外，我们通过亚组分析检查了轻度至中度饮酒是否对CVD发生具有保护作用。方法本研究对酒精消费与CVD发病率之间的关系进行了荟萃分析，选择了截至2017年12月出版的期刊。酒精消费水平分为非消费者，轻度（0.01-10.0 g /天），轻度至中度（10.1-20.0 g /天），中度（20.1-40.0 g /天），中度至高度（40.1-60.0 g /天）和高（> 60.0 g /天）组。根据合并症的数量和年龄进行亚组分析。结果总共选择了七篇文章进行荟萃分析。纽卡斯尔-渥太华量表的平均得分为8.14分，表明研究质量很高。仅男性饮酒水平和CVD发病率之间呈J形剂量反应关系。一般而言，轻度至中度和中度消耗可降低CVD的发生率（相对风险（RR）[95％置信区间（CI）]分别为0.68 [0.57-0.81]和0.72 [0.58-0.90]）。在3-4例合并症的男性中，轻度至中度和中度食用对心血管疾病的发生没有保护作用。在只有男性或男性和女性的两组中，仅中度和中度饮食对41岁至65岁的人有保护作用。讨论我们发现，轻度至中度和中等度饮酒对CVD的发生有保护作用，至少有3种合并症或40岁以下的人没有保护作用。结论我们得出结论，并不是所有的当地社区居民都经历了轻度至中度食用对心血管疾病发生率的保护作用。因此，有必要为每个人推荐适量的饮酒量或更少。