BACKGROUND Gastric cancer pathogenesis represents a complex interaction of host genetic determinants, microbial virulence factors and environmental exposures. Our primary aim was to determine the association between occupations/occupational exposures and odds of gastric cancer. METHODS We conducted a pooled-analysis of individual-level data harmonized from 11 studies in the Stomach cancer Pooling Project. Multivariable logistic regression was used to estimate the odds ratio (OR) of gastric cancer adjusted for relevant confounders. RESULTS A total of 5279 gastric cancer cases and 12 297 controls were analysed. There were higher odds of gastric cancer among labour-related occupations, including: agricultural and animal husbandry workers [odds ratio (OR) 1.33, 95% confidence interval (CI): 1.06-1.68]; miners, quarrymen, well-drillers and related workers (OR 1.70, 95% CI: 1.01-2.88); blacksmiths, toolmakers and machine-tool operators (OR 1.41, 95% CI: 1.05-1.89); bricklayers, carpenters and construction workers (OR 1.30, 95% CI: 1.06-1.60); and stationary engine and related equipment operators (OR 6.53, 95% CI: 1.41-30.19). The ORs for wood-dust exposure were 1.51 (95% CI: 1.01-2.26) for intestinal-type and 2.52 (95% CI: 1.46-4.33) for diffuse-type gastric cancer. Corresponding values for aromatic amine exposure were 1.83 (95% CI: 1.09-3.06) and 2.92 (95% CI: 1.36-6.26). Exposure to coal derivatives, pesticides/herbicides, chromium, radiation and magnetic fields were associated with higher odds of diffuse-type, but not intestinal-type gastric cancer. CONCLUSIONS Based on a large pooled analysis, we identified several occupations and related exposures that are associated with elevated odds of gastric cancer. These findings have potential implications for risk attenuation and could be used to direct investigations evaluating the impact of targeted gastric cancer prevention/early detection programmes based on occupation.

中文翻译：

---

职业暴露和胃癌几率：StoP 项目联盟汇总分析。

背景技术胃癌发病机制代表宿主遗传决定因素、微生物毒力因素和环境暴露之间复杂的相互作用。我们的主要目的是确定职业/职业暴露与胃癌几率之间的关联。方法 我们对胃癌汇集项目中 11 项研究的个人数据进行了汇总分析。使用多变量逻辑回归来估计针对相关混杂因素进行调整后的胃癌的比值比 (OR)。结果 共分析了 5279 例胃癌病例和 12 297 例对照。与劳动相关的职业中胃癌的发病率较高，包括：农业和畜牧业工人[比值比（OR）1.33，95%置信区间（CI）：1.06-1.68]；矿工、采石工人、钻井工人及相关工人（OR 1.70，95% CI：1.01-2.88）；铁匠、工具制造商和机床操作员（OR 1.41，95% CI：1.05-1.89）；瓦工、木匠和建筑工人（OR 1.30，95% CI：1.06-1.60）；以及固定式发动机和相关设备操作员（OR 6.53，95% CI：1.41-30.19）。肠型胃癌木屑暴露的 OR 为 1.51 (95% CI: 1.01-2.26)，弥漫型胃癌为 2.52 (95% CI: 1.46-4.33)。芳香胺暴露的相应值为 1.83 (95% CI: 1.09-3.06) 和 2.92 (95% CI: 1.36-6.26)。接触煤炭衍生物、杀虫剂/除草剂、铬、辐射和磁场与弥漫型胃癌的发病率较高有关，但与肠型胃癌的发病率无关。结论 基于大型汇总分析，我们确定了与胃癌发病率升高相关的几种职业和相关暴露。这些发现对风险减弱具有潜在影响，可用于指导评估基于职业的有针对性的胃癌预防/早期检测计划的影响的调查。