Staphylococcal nuclease and Tudor domain containing 1 (SND1) is an evolutionarily conserved protein present in eukaryotic cells from protozoa to mammals. SND1 has gained importance because it is overexpressed in aggressive cancer cells and diverse primary tumors. Indeed, it is regarded as a marker of cancer malignity. A broad range of molecular functions and the participation in many cellular processes have been attributed to SND1, mostly related to the regulation of gene expression. An increasing body of evidence points to a relevant relationship between SND1 and lipid metabolism. In this review, we summarize the knowledge about SND1 and its molecular and functional relationship with lipid metabolism. We highlight that SND1 plays a direct role in the regulation of cholesterol metabolism by affecting the activation of sterol response element-binding protein 2 (SREBP2) and we propose that that might have implications in the response of lipid homeostasis to stress situations.

中文翻译：

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分子和细胞洞察力，了解SND1在脂质代谢中的作用。

葡萄球菌核酸酶和含有1的Tudor结构域（SND1）是从原生动物到哺乳动物的真核细胞中存在的一种进化保守蛋白。SND1已变得很重要，因为它在侵袭性癌细胞和各种原发性肿瘤中过表达。实际上，它被认为是恶性肿瘤的标志。广泛的分子功能和许多细胞过程的参与已归因于SND1，主要与基因表达的调节有关。越来越多的证据表明SND1与脂质代谢之间存在相关关系。在这篇综述中，我们总结了有关SND1的知识及其与脂质代谢的分子和功能关系。