Chemical investigation on the peels of the cultivated edible mushroom Wolfiporia cocos led to the identification of 13 diterpenes and 4 steroids, including two new abietane diterpenes (1 and 2) and one new pregnane steroid (14). Structures of new compounds were determined by analysis of NMR, MS, and electronic circular dichroism (ECD) data. All compounds were evaluated for cytotoxicity (K562 and HepG2), antimicrobial and anti-inflammatory activity. Compounds 15, 17 showed strong cytotoxicity on K562 cells with the IC₅₀ values of 5.4 and 7.5 μM, respectively. Compounds 4, 9 and 17 displayed medium antibacterial activity against Staphylococcus aureus with MICs of 31.3, 48.5 and 12.5 μM, respectively. Compounds 1-10, 14 and 16 showed inhibitory activity on the NO (nitric oxide) release in LPS-induced RAW 264.7 cells with IC₅₀ values at the range of 16.8–75.8 μM. This work confirms the potential of peels of W. cocos in the treatment of infection diseases.

对栽培食用蘑菇枸杞果皮的化学研究导致鉴定出13种二萜和4种类固醇，其中包括2种新的Abetanene二萜（1和2）和一种新的孕烷类固醇（14）。通过分析NMR，MS和电子圆二色性（ECD）数据来确定新化合物的结构。评价所有化合物的细胞毒性（K562和HepG2），抗微生物和抗炎活性。化合物15，17显示对K562细胞的细胞毒性强与IC ₅₀的5.4和7.5的值μ男，分别。化合物4、9和17对培养基显示出中等的抗菌活性金黄色葡萄球菌与31.3，48.5和12.5的MIC μ分别男，。化合物1-10，14和16显示出对在LPS诱导的RAW 264.7细胞的NO（一氧化氮）释放与IC抑制活性₅₀值在16.8-75.8μM的范围内。这项工作证实了W. cocos果皮在治疗感染疾病中的潜力。