During spatial learning, hippocampal (HPC) place maps reorganize to represent new goal locations, but little is known about the circuit mechanisms facilitating these changes. Here, we examined how neuromodulation via locus coeruleus (LC) projections to HPC area CA1 (LC-CA1) regulates the overrepresentation of CA1 place cells near rewarded locations. Using two-photon calcium imaging, we monitored the activity of LC-CA1 fibers in the mouse dorsal HPC. We find that the LC-CA1 projection signals the translocation of a reward, predicting behavioral performance on a goal-oriented spatial learning task. An optogenetic stimulation mimicking this LC-CA1 activity induces place cell reorganization around a familiar reward, while its inhibition decreases the degree of overrepresentation around a translocated reward. Our results show that LC acts in conjunction with other factors to induce goal-directed reorganization of HPC representations and provide a better understanding of the role of neuromodulatory actions on HPC place map plasticity.

中文翻译：

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空间奖励学习过程中海马CA1地方细胞重组中的蓝斑基因的作用。

在空间学习过程中，海马（HPC）位置图会重新组织以表示新的目标位置，但对促进这些变化的电路机制知之甚少。在这里，我们检查了通过轨迹蓝藻（LC）投射到HPC区域CA1（LC-CA1）的神经调节如何调节奖励位置附近CA1位置细胞的过度表达。使用双光子钙成像，我们监测了小鼠背HPC中LC-CA1纤维的活性。我们发现，LC-CA1投影信号奖励的易位，预测目标为目标的空间学习任务上的行为表现。模仿这种LC-CA1活性的光遗传学刺激会诱导熟悉的奖励周围的位置细胞重组，而其抑制作用会降低易位奖励周围的过度表达程度。