We unfortunately found a couple of errors in the calculation of CL_{uptake,1B1+1B3,RAF} values for lot OJE. The published CL_{uptake,1B1+1B3,RAF} values for lot OJE were calculated with incorrect RAF_1B1 and RAF_1B3 values (5.74 and 0.414, respectively). As shown in Table 1, the correct RAF_1B1 and RAF_1B3 values for lot OJE were 3.65 and 0.627, respectively, which provided the CL_{uptake,1B1+1B3,RAF} values in the amended Table 3 shown herein. By using the correct RAF_1B1 and RAF_1B3 values, the contribution of OATP1B1 ranged from 86.4% (fexofenadine) to 99.3% (torasemide) in lot OJE. RAF-based net uptake clearance mediated by OATP1B1 and OATP1B3 (CL_{uptake,1B1+1B3,RAF}) was predictive of human hepatocyte PS_inf,act values within or close to 3-fold errors in lot OJE, in which the PS_inf,act values of fexofenadine and fluvastatin were 3.9- and 3.3-fold greater than the CL_{uptake,1B1+1B3,RAF} values, respectively. We have confirmed that the calculation errors happened only to lot OJE, and CL_{uptake,1B1+1B3,RAF} values obtained for lot VRR are correct. The conclusion drawn from this work is not affected by this error. The authors regret this error and deeply apologize for any inconvenience that may have been brought to the readers.(1−4) NA, not applicable because the OATP1B1- and OATP1B3-mediated uptake of telmisartan was not observed in transporter-transfected HEK293 cells in this study. The PS_inf,act of test compounds in two batches of human hepatocytes (lots VRR and OJE) was calculated according to eq 6 by using PS_inf,37 °C and PS_inf,ice values (Table S1). 1B1 contribution (%) = RAF_1B1 × CL_uptake,1B1/(RAF_1B1 × CL_uptake,1B1 + RAF_1B3 × CL_uptake,1B3) × 100. 1B3 contribution (%) = RAF_1B3 × CL_uptake,1B3/(RAF_1B1 × CL_uptake,1B1 + RAF_1B3 × CL_uptake,1B3) × 100. CL_{uptake,1B1+1B3,RAF} = RAF_1B1 × CL_uptake,1B1 + RAF_1B3 × CL_uptake,1B3. Accordingly, Figure 5B and Table of Contents/Abstract Graphic are amended to This article references 4 other publications.

中文翻译：

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基于相对活性因子（RAF）的人类肝脏细胞中有机阴离子转运多肽（OATP）1B1和OATP1B3介导的摄取清除的缩放。

不幸的是，我们在计算_OJE的CL_{吸收，1B1 + 1B3，RAF}值时发现了两个错误。使用错误的RAF _1B1和RAF _1B3值（分别为5.74和0.414）来计算已发布的_OJE的CL_{摄取，1B1 + 1B3，RAF}值。如表1所示，批次OJE的正确RAF _1B1和RAF _1B3值分别为3.65和0.627，这在此处显示的修订表3中提供了CL_{吸收，1B1 + 1B3，RAF}值。通过使用正确的RAF _1B1和RAF _1B3在OJE批次中，OATP1B1的贡献范围从86.4％（非索非那定）到99.3％（torasemide）。由OATP1B1和OATP1B3介导的基于RAF的净摄取清除（CL_{摄取，1B1 + 1B3，RAF}）可预测人肝细胞PS _inf，作用值在OJE批次内或接近3倍误差，其中PS会_起作用Fexofenadine和fluvastatin的值分别比CL_{摄取，1B1 + 1B3和RAF}值分别高3.9和3.3倍。我们已经确认，计算错误仅发生在批次OJE和CL_{摄取，1B1 + 1B3，RAF上}为批次VRR获得的值是正确的。从这项工作得出的结论不受此错误的影响。作者对此错误表示遗憾，并对可能给读者带来的任何不便深表歉意。（1-4）NA，不适用，因为在转运蛋白转染的HEK293细胞中未观察到OATP1B1和OATP1B3介导的替米沙坦摄取。这项研究。的PS _INF，充当根据通过使用PS到等式6在人肝细胞（批次VRR和OJE）计算的两批试验化合物的_INF，37℃和PS _INF，冰值（表S1）。1B1贡献（％）= RAF _1B1 ×CL_摄取，1B1 / /（RAF _1B1 ×CL_摄取，1B1 + RAF _1B3×CL_摄取，1B3）×100.1B3贡献（％）= RAF _1B3 ×CL_摄取，1B3 /（RAF _1B1 ×CL_摄取，1B1 + RAF _1B3 ×CL_摄取，1B3）× _{100.CL摄取，1B1 + 1B3， RAF} = RAF _1B1 ×CL_摄取，1B1 + RAF _1B3 ×CL_摄取，1B3。因此，图5B和目录/摘要图形被修改为本文参考其他4个出版物。