Practical Synthesis of High‐Performance Amino Tf‐Amide Organocatalysts for Asymmetric Aldol Reactions,Asian Journal of Organic Chemistry

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Practical Synthesis of High‐Performance Amino Tf‐Amide Organocatalysts for Asymmetric Aldol Reactions
Asian Journal of Organic Chemistry ( IF 2.8 ) Pub Date : 2020-01-27 , DOI: 10.1002/ajoc.201900730
Hanbin Lu ₁ , Jiamin Lv ₁ , Canhua Zhou ₁ , Terumasa Kato ₁ , Yan Liu ₁ , Keiji Maruoka _{1,

2}

Affiliation

A type of optically pure secondary‐amino aromatic Tf‐amide organocatalysts can be easily prepared from commercially available L‐hydroxyproline. The chemical behavior of these organocatalysts was investigated by the application to asymmetric aldol reactions. Among these, catalyst 2 a efficiently catalyzed direct asymmetric aldol reactions of cycloalkanones and substituted benzaldehydes, which afforded the corresponding aldol adducts in good yield with good to excellent anti‐diastereo and enantioselectivity.

中文翻译：

高效合成氨基Tf-酰胺有机催化剂的不对称Aldol反应的实用合成

可以从市售L-羟脯氨酸轻松制备一种光学纯的仲氨基芳族Tf-酰胺有机催化剂。通过将有机催化剂应用于不对称的羟醛反应研究了这些有机催化剂的化学行为。在这些中，催化剂2a的环烷酮和取代的苯甲醛的有效催化的直接不对称醇醛反应，得到相应的醛醇加合物以良好的收率具有良好至优良的抗-diastereo和对映选择性。

更新日期：2020-01-27

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