当前位置：
X-MOL 学术
›
J. Appl. Polym. Sci.
›
论文详情
Our official English website, www.x-mol.net, welcomes your
feedback! (Note: you will need to create a separate account there.)
Bovine serum albumin gel/polyelectrolyte complex of hyaluronic acid and chitosan based microcarriers for Sorafenib targeted delivery
Journal of Applied Polymer Science ( IF 2.7 ) Pub Date : 2020-01-21 , DOI: 10.1002/app.49002 Violeta Paşcalău 1 , Mihaela Tertis 2 , Emoke Pall 3 , Maria Suciu 4 , Traian Marinca 1 , Marius Pustan 1 , Violeta Merie 1 , Iulia Rus 2 , Cristian Moldovan 5 , Tamara Topala 2 , Codruta Pavel 1 , Catalin Popa 1
Journal of Applied Polymer Science ( IF 2.7 ) Pub Date : 2020-01-21 , DOI: 10.1002/app.49002 Violeta Paşcalău 1 , Mihaela Tertis 2 , Emoke Pall 3 , Maria Suciu 4 , Traian Marinca 1 , Marius Pustan 1 , Violeta Merie 1 , Iulia Rus 2 , Cristian Moldovan 5 , Tamara Topala 2 , Codruta Pavel 1 , Catalin Popa 1
Affiliation
|
The development of systems for targeted delivery of Sorafenib in unresectable hepatocellular carcinoma to reduce the systemic toxicity is a challenge. In our article, we successfully prepared core‐shell microcapsules based on bovine serum albumin gel with polyelectrolyte complex multilayer shell of polysaccharides with opposite charges, hyaluronic acid, and chitosan, encapsulating Sorafenib, as targeting delivery system for improved hepatocellular carcinoma therapy. A bovine serum albumin gel core was formed by a method based on a sacrificial CaCO3 template, followed by the multilayer shell build‐up of Ca2+ cross‐linked hyaluronic acid hydrogel, and subsequently alternating multilayers of the polyelectrolyte complex formed between hyaluronic acid and chitosan. The following techniques: Fourier‐transform infrared and UV–Vis spectroscopy, X‐ray diffraction, differential scanning calorimetry, confocal laser scanning microscopy, atomic force microscopy, and scanning electron microscopy were used for the physicochemical characterization. These tests revealed the spherical shape of core‐shell type, the micro‐size, as well as the composition of microcapsules after their synthesis and proved the successful encapsulation and release of the drug. The promising results regarding encapsulation efficiency, Sorafenib release profile and cytotoxicity on HepG2 and mesenchymal stem cells, recommend Sorafenib loaded microcapsules as suitable targeted drug carriers for further in vivo studies for hepatocellular carcinoma therapy.
中文翻译：
牛透明质酸和壳聚糖微载体的牛血清白蛋白凝胶/聚电解质复合物用于索拉非尼靶向递送
索拉非尼在不可切除的肝细胞癌中靶向递送以降低全身毒性的系统的开发是一项挑战。在我们的文章中，我们成功地制备了基于牛血清白蛋白凝胶的核壳微胶囊，该胶囊具有带相反电荷的透明质酸和壳聚糖的聚电解质复合多层壳，包裹了索拉非尼，作为靶向递送系统，可改善肝细胞癌治疗。通过基于牺牲CaCO 3模板的方法形成牛血清白蛋白凝胶核心，然后形成多层的Ca 2+壳层交联的透明质酸水凝胶，然后在透明质酸和壳聚糖之间交替形成多层聚电解质复合物。以下技术用于理化特性分析：傅立叶变换红外和UV-Vis光谱，X射线衍射，差示扫描量热法，共聚焦激光扫描显微镜，原子力显微镜和扫描电子显微镜。这些测试揭示了核-壳型的球形，微尺寸以及合成后的微胶囊的组成，并证明了药物的成功包封和释放。关于包封效率，索拉非尼释放曲线以及对HepG2和间充质干细胞的细胞毒性的有希望的结果，
更新日期：2020-01-21
中文翻译：
牛透明质酸和壳聚糖微载体的牛血清白蛋白凝胶/聚电解质复合物用于索拉非尼靶向递送
索拉非尼在不可切除的肝细胞癌中靶向递送以降低全身毒性的系统的开发是一项挑战。在我们的文章中，我们成功地制备了基于牛血清白蛋白凝胶的核壳微胶囊，该胶囊具有带相反电荷的透明质酸和壳聚糖的聚电解质复合多层壳，包裹了索拉非尼，作为靶向递送系统，可改善肝细胞癌治疗。通过基于牺牲CaCO 3模板的方法形成牛血清白蛋白凝胶核心，然后形成多层的Ca 2+壳层交联的透明质酸水凝胶，然后在透明质酸和壳聚糖之间交替形成多层聚电解质复合物。以下技术用于理化特性分析：傅立叶变换红外和UV-Vis光谱，X射线衍射，差示扫描量热法，共聚焦激光扫描显微镜，原子力显微镜和扫描电子显微镜。这些测试揭示了核-壳型的球形，微尺寸以及合成后的微胶囊的组成，并证明了药物的成功包封和释放。关于包封效率，索拉非尼释放曲线以及对HepG2和间充质干细胞的细胞毒性的有希望的结果，
京公网安备 11010802027423号