Powders of β-tricalcium phosphate [β-TCP, β-Ca3(PO4)2] and composite powders of β-TCP and polyvinyl alcohol (PVA) were synthesized by using wet precipitation methods. First, the conditions for the preparation of single phase β-TCP have been delineated. In the co-precipitation procedure, calcium nitrate and diammonium hydrogen phosphate were used as calcium and phosphorous precursors, respectively. The pH of the system was varied in the range 7-11 by adding designed amounts of ammonia solution. The filtered cakes were desiccated at 80 °C and subsequently calcined at different temperatures in the range between 700-1100 °C. Later on, rifampicin form II was used to produce drug-loaded β-TCP and PVA/β-TCP powders. All the synthesized materials have been characterized from morphological (by scanning electron microscopy) and structural-chemical (by X-ray diffraction and Fourier transform infrared spectroscopy) point of view. The drug loading capacity of the selected pure β-TCP powder has been assessed. The biological performance (cytocompatibility in fibroblast cell culture and antibacterial efficacy against Escherichia coli and Staphylococcus aureus) has been tested with promising results. Application perspectives of the designed drug-bioceramic-polymer blends are advanced and discussed.

中文翻译：

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用于骨工程应用的载有抗菌药物的β-磷酸三钙粉的合成与表征。

采用湿法沉淀法合成了β-磷酸三钙[β-TCP，β-Ca3（PO4）2]粉末以及β-TCP和聚乙烯醇（PVA）复合粉末。首先，已经描述了制备单相β-TCP的条件。在共沉淀过程中，硝酸钙和磷酸氢二铵分别用作钙和磷的前体。通过添加设计量的氨溶液，系统的pH在7-11的范围内变化。将滤饼在80℃下干燥，然后在700-1100℃之间的不同温度下煅烧。后来，II型利福平被用于生产载药的β-TCP和PVA /β-TCP粉末。从形态学（通过扫描电子显微镜）和结构化学（通过X射线衍射和傅里叶变换红外光谱）的角度对所有合成材料进行了表征。已评估了所选纯β-TCP粉末的载药量。已测试了生物学性能（成纤维细胞培养中的细胞相容性以及对大肠杆菌和金黄色葡萄球菌的抗菌功效），并获得了可喜的结果。提出并讨论了设计的药物-生物陶瓷-聚合物共混物的应用前景。已测试了生物学性能（成纤维细胞培养中的细胞相容性以及对大肠杆菌和金黄色葡萄球菌的抗菌功效），并获得了可喜的结果。提出并讨论了设计的药物-生物陶瓷-聚合物共混物的应用前景。已测试了生物学性能（成纤维细胞培养中的细胞相容性以及对大肠杆菌和金黄色葡萄球菌的抗菌功效），并获得了可喜的结果。提出并讨论了设计的药物-生物陶瓷-聚合物共混物的应用前景。