The restricted mean survival time (RMST) is a relatively new parameter proposed to improve the analysis of survival curves. As opposed to the median, the RMST has the advantage of capturing the overall shape of the survival curve, including the so-called “right tail.” One limitation of RMST lies in the mathematical complexity of its calculation (model-dependent analysis). In the present report, we describe a model-independent method that simplifies the calculation of RMST. The estimation approach (trapezoidal rule) is the same as that commonly employed in pharmacokinetics. In the analysis of 6 survival curves, the performance of the model-independent method was virtually the same as that of model-dependent methods.

中文翻译：

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生存曲线分析中确定受限平均生存时间的独立于模型的方法

受限平均生存时间（RMST）是为改善生存曲线分析而提出的一个相对较新的参数。与中位数相反，RMST的优势在于可以捕获生存曲线的整体形状，包括所谓的“右尾巴”。RMST的局限性在于其计算（与模型有关的分析）的数学复杂性。在本报告中，我们描述了一种独立于模型的方法，该方法简化了RMST的计算。估算方法（梯形法则）与药代动力学中常用的方法相同。在分析6条生存曲线时，与模型无关的方法的性能与与模型无关的方法的性能几乎相同。