Primary neurolymphomatosis (NL) is a rare condition that refers to lymphomas primarily presenting in cranial or peripheral nerves. Similar to primary central nervous system lymphoma (PCNSL), almost all cases of neurolymphomatosis are histologically classified as high-grade diffuse B cell lymphoma. Primary involvement of cranial nerves is extremely rare and manifests with signs and symptoms of mass effect. We present the case of a 67-year-old right-handed male who presented to hospital with progressive horizontal diplopia and left facial numbness in the V1 and V2 distributions. The patient subsequently developed ataxia, dizziness, and nausea. An open biopsy was performed which confirmed the diagnosis of diffuse B cell lymphoma. The patient experienced rapid clinical improvement after the administration of chemotherapy. A comprehensive search of literature using the MEDLINE and EMBASE database yielded 9 previous cases of primary neurolymphomatosis in the cranial nerves and these are reviewed here. However, to date, this is the first reported case involving the trigeminal nerve in the cavernous sinus while concurrently causing mass effect on the lower cranial nerves.

中文翻译：

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海绵窦和脑干的原发性神经淋巴瘤病。病例报告及文献复习

原发性神经淋巴瘤病（NL）是一种罕见的疾病，指主要存在于颅神经或周围神经中的淋巴瘤。与原发性中枢神经系统淋巴瘤（PCNSL）相似，几乎所有神经淋巴瘤病病例在组织学上都被分类为高度弥漫性B细胞淋巴瘤。颅神经主要累及极为罕见，表现为肿块迹象和症状。我们介绍了一个67岁的惯用右手的男性患者，该患者在V1和V2分布中出现进行性水平复视和左侧面部麻木。患者随后出现共济失调，头晕和恶心。进行了活检，证实了弥漫性B细胞淋巴瘤的诊断。化疗后患者临床快速改善。使用MEDLINE和EMBASE数据库对文献进行全面搜索，得出9例先前的颅神经原发性神经淋巴瘤病病例，在此进行了综述。然而，迄今为止，这是第一例报道的海绵窦三叉神经，同时对下颅神经造成质量影响的病例。