High prevalence and viremia of human pegivirus 2 in the HIV-infected population in Honghe Prefecture, Yunnan Province.,Archives of Virology

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High prevalence and viremia of human pegivirus 2 in the HIV-infected population in Honghe Prefecture, Yunnan Province.
Archives of Virology ( IF 2.5 ) Pub Date : 2020-01-21 , DOI: 10.1007/s00705-019-04512-6
Tianyi Li ₁ , Shixing Tang _{2,

3} , Yingying Su ₄ , Zuoyi Bao ₁ , Xiaolin Wang ₁ , Yongjian Liu ₁ , Hanping Li ₁ , Jingwan Han ₁ , Zhichao Pei ₁ , Zhengwei Wan _{2,

3} , Hang Fan ₁ , Yigang Tong ₁ , Lin Li ₁ , Ning Wang ₄ , Jingyun Li ₁

Affiliation

Human pegivirus 2 (HPgV-2) is a recently recognized pegivirus of the family Flaviviridae. To investigate the epidemic features of HPgV-2 circulating in the human immunodeficiency virus (HIV)-infected population, we tested for antibodies and viral RNA of HPgV-2 and hepatitis C virus (HCV) with retrospective plasma samples collected from 771 HIV infections with multiple risk behaviors in Honghe Prefecture of Yunnan Province. A total of 195 subjects (25.29%) were seroreactive to HPgV-2, and 41 (5.32%) were RNA positive. Although the positive rate of HPgV-2 antibodies in HIV/HCV-coinfected individuals (27.69%) was significantly higher than that of HIV monoinfections (20.82%) (p = 0.036), this is the first report of HPgV-2 viremia in HIV-infected individuals without HCV infection and the presence of two HPgV-2 lineages in China. Our data indicate that HPgV-2 can also be transmitted sexually, which might be facilitated when combined with HCV infection, injecting drug use, and risky sexual behavior, which appear to have a synergistic effect on HPgV-2 infection. Phylogenetic analysis of 26 near-full-length genome sequences showed that the HPgV-2 strains in China are divided into two clusters.

更新日期：2020-01-22

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