AIMS Physical activity reduces cardiovascular disease burden and mortality, although its relationship with cardiac arrhythmias is less certain. The aim of this study was to assess the association between self-reported physical activity and atrial fibrillation (AF), ventricular arrhythmias and bradyarrhythmias, across the UK Biobank cohort. METHODS AND RESULTS We included 402 406 individuals (52.5% female), aged 40-69 years, with over 2.8 million person-years of follow-up who underwent self-reported physical activity assessment computed in metabolic equivalent-minutes per week (MET-min/wk) at baseline, detailed physical assessment and medical history evaluation. Arrhythmia episodes were diagnosed through hospital admissions and death reports. Incident AF risk was lower amongst physically active participants, with a more pronounced reduction amongst female participants [hazard ratio (HR) for 1500 vs. 0 MET-min/wk: 0.85, 95% confidence interval (CI) 0.74-0.98] than males (HR for 1500 vs. 0 MET-min/wk: 0.90, 95% CI 0.82-1.0). Similarly, we observed a significantly lower risk of ventricular arrhythmias amongst physically active participants (HR for 1500 MET-min/wk 0.78, 95% CI 0.64-0.96) that remained relatively stable over a broad range of physical activity levels between 0 and 2500 MET-min/wk. A lower AF risk amongst female participants who engaged in moderate levels of vigorous physical activity was observed (up to 2500 MET-min/wk). Vigorous physical activity was also associated with reduced ventricular arrhythmia risk. Total or vigorous physical activity was not associated with bradyarrhythmias. CONCLUSION The risk of AF and ventricular arrhythmias is lower amongst physically active individuals. These findings provide observational support that physical activity is associated with reduced risk of atrial and ventricular arrhythmias.

中文翻译：

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402 406 个人体力活动与发生心律失常风险之间的关联：来自英国生物银行队列的证据

AIMS 体力活动可降低心血管疾病负担和死亡率，但其与心律失常的关系尚不确定。本研究的目的是评估英国生物银行队列中自我报告的体力活动与心房颤动 (AF)、室性心律失常和缓慢性心律失常之间的关联。方法和结果 我们纳入了 402406 人（52.5% 女性），年龄在 40-69 岁之间，随访超过 280 万人年，他们接受了自我报告的身体活动评估，以每周代谢当量分钟数（MET- min/wk) 在基线、详细的身体评估和病史评估。心律失常发作是通过住院和死亡报告来诊断的。身体活跃的参与者发生 AF 的风险较低，与男性相比，女性参与者 [1500 对 0 MET-分钟/周的风险比 (HR)：0.85，95% 置信区间 (CI) 0.74-0.98] 降低更明显（HR 为 1500 对 0 MET-分钟） /周：0.90，95% CI 0.82-1.0）。同样，我们观察到体力活动参与者的室性心律失常风险显着降低（1500 MET-min/wk 的 HR 0.78，95% CI 0.64-0.96）在 0 到 2500 MET 之间的广泛体力活动水平上保持相对稳定-分钟/周。在从事中等强度体力活动的女性参与者中观察到较低的 AF 风险（高达 2500 MET-min/wk）。剧烈的体力活动也与室性心律失常风险降低有关。完全或剧烈的体力活动与缓慢性心律失常无关。结论 身体活跃的个体发生 AF 和室性心律失常的风险较低。这些发现提供了观察性支持，即体育锻炼与降低房性和室性心律失常的风险相关。